Childrens Monkey Fold Away Chair

Product Information

Blood glucose, body temperature and physical activities were continuously and simultaneously recorded by implanted HD-XG telemetry device for up to 10 weeks. Results and discussion

Li Y, Xu W, Liao Z, Yao B, Chen X, Huang Z, Hu G, Weng J (2004) Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of beta-cell function. Diabetes Care 27(11):2597–2602 Positioning furniture can help take the strain off of your body and enable you to try positions you might not be able to otherwise. That could be something as simple as a cushion to support your spine and reduce your pain or something more involved like a sex bench to hold limbs in place. You’re really only limited here by your imagination. Plus the chair is easy to assemble and then take apart again for storage. It’s built to hold up to 300 pounds. For more substantial pieces you'll need a dedicated spot or be willing to stash them in a closet or other storage area.To make it extra spicy, there’s a slot in the center of the seat where you can put an insertable toy and then sit your sub right down on it and hold them there with the restraints. The chair comes with a toy to start with that fits the slot but be warned that it’s quite realistic if that’s not your general toy preference. To support the research community to refine restraint training of non-human primates we have co-sponsored, over four consecutive years, an 8-hour training workshop on ‘Teaching monkeys to cooperate with restraint: using positive reinforcement training and temperament testing methods’, held at the AALAS National Meeting in the USA. Working group membership Name To validate the reliability of the telemetry method, blood glucose levels were measured at different time points and with or without various challenges 1 week after device implantation. During the study, 187 blood glucose parameters were collected by both telemetry and glucometer methods in normoglycemic ( n = 3) and diabetic ( n = 2) monkeys. The blood glucose levels measured by the telemetry method were highly correlated with those read by the glucometer (Fig. 1d, Y = 0.9804 x + 3.2753, R² = 0.9466, p< 0.001), which suggests that the telemetry method with the implantable HD-XG device is reliable for continuous blood glucose monitoring. Blood glucose fluctuations during daily activities This Spanking Bench is made right here in the USA using real hardwood and metal, so if you’re looking for a substantial piece that you can trust to be sturdy, this is for you. Clinically, the FDA-approved Continuous Glucose Monitoring (CGM) system (Dexcom G4 PLATINUM Continuous Glucose Monitoring System, Dexcom, Inc., San Diego, CA, USA) can sense interstitial glucose frequently in diabetic patients to inform exogenous insulin delivery timing and dosage. Compared with the arterial glucose telemetry monitoring method used in this study, the advantages of the clinical CGM system (subcutaneously) are relatively easier installation, less expensive, less invasive, and more acceptable safety profile which becomes the mainstay for patient use. For animal research, the disadvantages of the clinic CGM system can firstly manifest moderately delayed glucose readings (5–12 min) [ 26– 29] and likely worsen with implantation time as encapsulation develops [ 30, 31]. Secondly, the CGM system readings of glucose level can vary due to local fluctuations of subcutaneous blood flow by the change of temperature and/or mechanical pressure [ 32, 33]. Thirdly, subcutaneously inflammatory response results in biofouling and encapsulation, which limits sensor service time (less than 2 weeks) [ 26, 34]. Fourthly, fixation of subcutaneously inserted sensor for stable data collection in physically active monkeys is very challenging. To stabilize implanted sensor and to avoid any delay of glucose reading, this study used the implanted HD-XG telemetry device to access arterial vasculature and provided real-time blood glucose information [ 12].

Kahn CR (1994) Banting lecture. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 43(8):1066–1084 To test insulin resistance and β-cell insulin secretory response to acute hyperglycemia, intravenous glucose tolerance test (ivGTT) was conducted. The experimental animals were fasted overnight (around 16 h) and anesthetized with ketamine at 10 mg/kg (i.m.) initially plus additional dose (5 mg/kg, i.m.) during the procedure if needed. When blood glucose stabilized for approximately 30 min via observation of HD-XG glucose signals, the glucose solution (0.25 g/kg = 0.5 mL/kg of 50% dextrose) was intravenously infused via one cephalic vein within 30 s, and then the system was flushed with 5 mL heparinized saline to push in the residual glucose. Holloszy JO (2005) Exercise-induced increase in muscle insulin sensitivity. J Appl Physiol 99(1):338–343

because NHPs can naturally develop Type 2 diabetes mellitus (T2DM) similarly to humans. This study was to investigate blood glucose changes in conscious, moving-free cynomolgus monkeys ( Macaca fascicularis) during circadian, meal, stress and drug exposure. Materials and methods Brijesh M (2015) Somogyi effect in a patient of type 2 diabetes mellitus. J Diabetes Metab 6:493 doi: 10.4172/2155-61561000493 Burnett DR, Huyett LM, Zisser HC, Doyle FJ 3rd, Mensh BD (2014) Glucose sensing in the peritoneal space offers faster kinetics than sensing in the subcutaneous space. Diabetes 63(7):2498–2505 With the addition of short lengths of chain, you can even create the 3D shapes shown in the images above by attaching the board to itself. Your flat bondage surface becomes a spanking chair or supportive wedge to bend a submissive over for all sorts of play. Dye L, Mansfield M, Lasikiewicz N, Mahawish L, Schnell R, Talbot D, Chauhan H, Croden F, Lawton C (2010) Correspondence of continuous interstitial glucose measurement against arterialised and capillary glucose following an oral glucose tolerance test in healthy volunteers. Br J Nutr 103(1):134–140

Single-point calibrations were performed to prevent non-physiologic changes in the baseline glucose value over time during the study. Non-physiologic changes include enzyme instability due to sensor drifting or fibrin and tissue growth on the sensor electrode. Single-point calibrations were performed at least twice per week at the same time of day and during a time period when the animal’s blood glucose was relatively stable. Data collection Harwood HJ Jr, Listrani P, Wagner JD (2012) Nonhuman primates and other animal models in diabetes research. J Diabetes Sci Technol 6(3):503–514

Where Do I Store My Sex Bench or Cushion?

Gough DA, Kumosa LS, Routh TL, Lin JT, Lucisano JY (2010) Function of an implanted tissue glucose sensor for more than 1 year in animals. Sci Transl Med 2(42):42ra53

It is interesting that compared with nighttime, blood glucose was relatively lower during most daytime in the normoglycemic monkeys, but not the case in the diabetic ones (Fig. 3). The daily circadian of blood glucose in the diabetes monkeys was higher during daytime with starting from very early morning (Fig. 3). This phenomenon could result from insulin resistance and relative insulin deficiency in diabetic NHPs, which is similar to the observation in diabetic patients [ 18]. Clinically, glucose circadian changes are influenced by levels of both insulin and the counter-regulatory hormones, such as glucagon, adrenaline, growth hormone, and cortisol. There is a surge in the amount of released growth hormone beginning from the middle night, followed by a surge in cortisol to increase liver blood glucose production. These processes are offset by increased insulin secretion to maintain blood glucose relatively stable in normoglycemic individuals. However, in diabetic patients, hormone changes during sleep can have a powerful effect on morning blood glucose level, an event dubbed the “dawn phenomenon” [ 19, 20].I love that it breaks down easily so you can store it flat under your bed. It’s built to hold up to 300 pounds. Xiao YF, Wang B, Wang X, Du F, Benzinou M, Wang YX (2013) Xylazine-induced reduction of tissue sensitivity to insulin leads to acute hyperglycemia in diabetic and normoglycemic monkeys. BMC Anesthesiol 13(1):33 As we get older, our bodies are less happy to put up with the wild positions we used to love and certain furniture can adapt those positions to make them comfortable again. ITT is used to examine if the body produces enough ACTH (adreno-cortico-trophic hormone) and growth hormone under stress. The ‘stress’ in this test was to lower blood sugar (hypoglycemia) by injected insulin under very controlled conditions. ACTH stimulates the adrenal glands to make cortisol which is a steroid hormone and has many functions, including balancing the effect of insulin in regulating blood glucose levels. Five animals (normoglycemia, n = 3 and diabetes, n = 2) were fasted overnight (16 h) and restrained in the monkey chair. When blood glucose levels stabilized for around 30 min via observation of the HD-XG glucose signals, the insulin solution (0.15 U/kg = 0.15 mL/kg of insulin injection) was given to each animal via S.C. injection [ 5]. Blood glucose levels were measured by the glucometer method (StatStrip Xpress meter) immediately before and at 30, 60, 90, and 120 min after insulin administration (Fig. 7, ITT). Meanwhile, blood glucose levels were monitored and recorded by implanted HD-XG devices. The results were plotted against the time and were correlated very well between the telemetry results and the glucometer readings. GGI Sasase T, Pezzolesi MG, Yokoi N, Yamada T, Matsumoto K (2013) Animal models of diabetes and metabolic disease. J Diabetes Res. doi: 10.1155/2013/281928