Protexin Veterinary Synbiotic D-C Daily probiotic and prebiotic capsules for dogs and cats (Pack of 1, 50 Capsules)

Product Information

Synbiotic 180-S is a 9 strain probiotic blend (180 million CFU/g) with natural prebiotic (chicory root extract) and enzymes, designed as a multi-species formula to improve overall health and wellbeing for all animals.

Closa-Monasterolo, R. et al. Safety and efficacy of inulin and oligofructose supplementation in infant formula: results from a randomized clinical trial. Clin. Nutr. 32, 918–927 (2013). I’ve been giving Synbiotic D-C Probiotic to both my labs for quite awhile now and the difference in their stools has been really noticeable. Shafaghi, A. et al. The effect of probiotic plus prebiotic supplementation on the tolerance and efficacy of Helicobacter pylori eradication quadruple therapy: a randomized prospective double blind controlled trial. Middle East J. Dig. Dis. 8, 179–188 (2016).Anderson, A. D., McNaught, C. E., Jain, P. K. & MacFie, J. Randomised clinical trial of synbiotic therapy in elective surgical patients. Gut 53, 241–245 (2004). Rossi, M. et al. Synbiotics easing renal failure by improving gut microbiology (SYNERGY): a randomized trial. Clin. J. Am. Soc. Nephrol. 11, 223–231 (2016).

Walker, A. W. & Lawley, T. D. Therapeutic modulation of intestinal dysbiosis. Pharmacol. Res. 69, 75–86 (2013). One regulatory consequence of probiotic and prebiotic definitions is that the European Union has determined that labelling a food product as such amounts to an implied health claim 90. As health claims in the European Union must be approved, the use of ‘probiotic’ or ‘prebiotic’ on a food label is subject to a health claim approval process. Despite controversy surrounding this situation, we can expect that the European Union might adopt a similar position for the use of the term ‘synbiotic’ because it also requires evidence of a health benefit. Scientists Dysbiosis index vs. next generation sequencing vs. metabolomics or immune system profiling. Is the ideal test a stool test, a serum biomarker, or a combination of tests? The panel updated the definition of a synbiotic to “a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host”. ‘Host’ microorganisms in this context include both autochthonous microorganisms (resident or colonizing the host) and allochthonous microorganisms (externally applied, such as probiotics), which, even if transiently present, do constitute a component of the host microbiota.Oliveira, R. P. et al. Effect of different prebiotics on the fermentation kinetics, probiotic survival and fatty acids profiles in nonfat symbiotic fermented milk. Int. J. Food Microbiol. 128, 467–472 (2009). Regulatory authorities are primarily focused on two issues: product safety and product labelling. These encompass both truthfulness and compliance with regulatory statutes. Even if the term synbiotic is not included in governmental guidelines or regulations, the use of our proposed scientific definition of the term will aid regulatory oversight of products labelled as ‘synbiotic’.

Studies on a synergistic synbiotic that compare the synbiotic to the control can provide supportive evidence but do not constitute the primary evidence needed to confirm a synergistic synbiotic. Instead, a study including the combination, the substrate alone, the live microorganisms alone and a control should be conducted. Using an appropriate statistical model, the aim is to demonstrate that the combined effect is better than the estimated effects of each component separately. Evidence of selective utilization of the substrate by the co-administered live microorganism must be obtained from the same trial demonstrating the health benefit. Trials for complementary synbiotics In a blinded four-arm study, 41 healthy volunteers received either Bifidobacterium animalis subsp. lactis Bi-07 (10 9 CFU per day), 8 g per day xylo-oligosaccharides (XOS), the combination of both or an inert maltodextrin control for 21 days 128. XOS enhanced bifidobacteria counts in faeces in both the synbiotic and prebiotic groups compared with the control and improved plasma lipid profiles and modulated markers of immune function in healthy adults. The lowest reported use of analgesics was observed during combination supplementation along with a reduced expression of CD19 on B cells (as markers of immune function). Thus, the combination exerted certain benefits that were not afforded by the probiotic or prebiotic alone. This study shows a prebiotic status for XOS used at 8 g per day. Previous evidence supports that Bifidobacterium animalis subsp. lactis Bi-07 at 10 9 CFU per day met criteria for a probiotic 112, 129. Taken together, this tested product meets our definition of a complementary synbiotic. However, because an increase of Bifidobacterium was not observed in individuals fed the combination product, it does not meet our definition of a synergistic synbiotic. Beneficial effect(s) of a synbiotic on health must be confirmed in the target host, which might include humans, companion animals, or agricultural species or a subpopulation (such as different age or developmental stage, health status, sex or living situation) thereof. Davis, L. M., Martinez, I., Walter, J. & Hutkins, R. A dose dependent impact of prebiotic galactooligosaccharides on the intestinal microbiota of healthy adults. Int. J. Food Microbiol. 144, 285–292 (2010).David, L. A. et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 505, 559–563 (2014). Rossi G, Pengo G, Caldin M, et al. Comparison of microbiological, histological, and immunomodulatory parameters in response to treatment with either combination therapy with prednisone and metronidazole or probiotic VSL#3 strains in dogs with idiopathic inflammatory bowel disease. PLoS One 2014;9(4):e94699. Probiotics are beneficial bacteria that can help to re-establish the normal microbiota. They are particularly effective when delivered together with a prebiotic, a source of nutrition that stimulates growth.