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Alfred W. McCoy. "Opium History, 1858 to 1940". Archived from the original on 4 April 2007 . Retrieved 4 May 2007.
a b c M J Brownstein (June 15, 1993). "A brief history of opiates, opioid peptides, and opioid receptors". Proceedings of the National Academy of Sciences of the United States of America. 90 (12): 5391–5393. Bibcode: 1993PNAS...90.5391B. doi: 10.1073/pnas.90.12.5391. PMC 46725. PMID 8390660. Between 400 and 1200 CE, Arab traders introduced opium to China, and to India by 700. [19] [1] [12] [20] The physician Muhammad ibn Zakariya al-Razi of Persian origin ("Rhazes", 845–930 CE) maintained a laboratory and school in Baghdad, and was a student and critic of Galen; he made use of opium in anesthesia and recommended its use for the treatment of melancholy in Fi ma-la-yahdara al-tabib, "In the Absence of a Physician", a home medical manual directed toward ordinary citizens for self-treatment if a doctor was not available. [21] [22]
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Opium contains two main groups of alkaloids. Phenanthrenes such as morphine, codeine, and thebaine are the main psychoactive constituents. [150] Isoquinolines such as papaverine and noscapine have no significant central nervous system effects. Morphine is the most prevalent and important alkaloid in opium, consisting of 10–16 percent of the total, and is responsible for most of its harmful effects such as lung edema, respiratory difficulties, coma, or cardiac or respiratory collapse. Morphine binds to and activates mu opioid receptors in the brain, spinal cord, stomach and intestine. Regular use can lead to drug tolerance or physical dependence. Chronic opium addicts in 1906 China [48] consumed an average of eight grams of opium daily; opium addicts in modern Iran [151] are thought to consume about the same. a b Hevia, James Louis (2003). "Opium, Empire, and Modern History" (PDF). China Review International. 10 (2): 307–326. doi: 10.1353/cri.2004.0076. ISSN 1527-9367. S2CID 143635262.
Simon O'Dochartaigh. "HON Mother & Child Glossary, Meconium". hon.ch. Archived from the original on May 1, 2021 . Retrieved April 4, 2016. The process continued until 1817, when Sertürner published his results after thirteen years of research and a nearly disastrous trial on himself and three boys. [102] The great advantage of purified morphine was that a patient could be treated with a known dose—whereas with raw plant material, as Gabriel Fallopius once lamented, "if soporifics are weak they do not help; if they are strong they are exceedingly dangerous." William Travis Hanes; Frank Sanello (2004). Opium Wars: The Addiction of One Empire and the Corruption of Another. Sourcebooks, Inc. pp.78–. ISBN 978-1-4022-0149-3. Opium is illegal in Australia. Federal and state laws provide penalties for possessing, using, cultivating or selling opium, or driving under its influence. Opium statistics Presley CC, Lindsley CW. DARK Classics in Chemical Neuroscience: opium, a historical perspective. ACS Chemical Neuroscience. 2018;9(10):2503-18.If you take a large amount of opium, you could overdose. Call an ambulance straight away by dialling triple zero (000) if you or another person have any of these symptoms (ambulance officers don’t need to involve the police):
Islamic Medical Manuscripts at the National Library of Medicine: a note on pharmaceutics" . Retrieved June 6, 2007.United States Congress Senate Committee on the Judiciary. Communist china and illicit narcotic traffic. 1955年: United States Government Printing Office. OCLC 6466332. {{ cite book}}: CS1 maint: location ( link) Though opium yields vary based on growing conditions, 2.5 acres (1 hectare) of poppies typically produce between 17.6 and 33 lbs. (8 to 15 kilograms) of raw opium, according to the book " Opium: A History" (St. Martin's Griffin, 1999). Estimated yields of heroin from raw opium are between 6 percent and 10 percent. Thus, the acre of poppies found in North Carolina would yield a little more than 13 lbs. (6 kg) of raw opium and 1.3 lbs. (0.6 kg) of heroin in a full growing season in the best of circumstances.
Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. 1 The Peony bar is Opium’s hidden gem, nestled somewhere within our labyrinthine corridors, behind the red curtain on the second floor. Peony has very different feel to the rest of the venue – it’s the Yang to Opium’s Ying and is often considered the most romantic room in the building. Despite being the smallest of all three bars it’s a great self-contained space for private party up to 30 guests, who will be served by your own bartender and look after for the duration of your stay with us. Exclusive hire of the Peony bar includes full waiting staff/bartenders and access to the sound system.
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Smoking of opium came on the heels of tobacco smoking and may have been encouraged by a brief ban on the smoking of tobacco by the Ming emperor. The prohibition ended in 1644 with the coming of the Qing dynasty, which encouraged smokers to mix in increasing amounts of opium. [1] In 1705, Wang Shizhen wrote, "nowadays, from nobility and gentlemen down to slaves and women, all are addicted to tobacco." Tobacco in that time was frequently mixed with other herbs (this continues with clove cigarettes to the modern day), and opium was one component in the mixture. Tobacco mixed with opium was called madak (or madat) and became popular throughout China and its seafaring trade partners (such as Taiwan, Java, and the Philippines) in the 17th century. [47] In 1712, Engelbert Kaempfer described addiction to madak: "No commodity throughout the Indies is retailed with greater profit by the Batavians than opium, which [its] users cannot do without, nor can they come by it except it be brought by the ships of the Batavians from Bengal and Coromandel." [20] Opium was prohibited in many countries during the early 20th century, leading to the modern pattern of opium production as a precursor for illegal recreational drugs or tightly regulated, highly taxed, legal prescription drugs. In 1980, 2,000 tons of opium supplied all legal and illegal uses. [20] Worldwide production in 2006 was 6610 tonnes [107]—about one-fifth the level of production in 1906; since then, opium production has fallen. [ citation needed] The opium trade under the Chinese Communist Party was important to its finances in the 1940s. [82] Peter Vladimirov's diary provided a first hand account. [83] Chen Yung-fa provided a detailed historical account of how the opium trade was essential to the economy of Yan'an during this period. [84] Mitsubishi and Mitsui were involved in the opium trade during the Japanese occupation of China. [85]
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