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Burkard AW, Ponterotto JG, Reynolds AL, Alfonso VC. White counselor trainees' racial identity and working alliance perceptions. Journal of Counseling and Development. 1999; 77(3):324–329. [ Google Scholar] We all know that one size does not mean one size. The fact that one pair of pants can fit four different girls perfectly, who all have different body types, is not realistic. Although the movie revolves around the jeans traveling from one friend to the next, it was more about the friendship of the four girls. They were apart but were able to be there for each other during the times when they needed someone. Well, that’s what we are meant to think.

When high performers move into leadership roles, one of the first choices they need to make is what kind of leader they want to be — and there are a lot of options to choose from. Some imagine themselves visionary leaders, ready to guide their teams through rough waters, or democratic leaders who want to encourage collaboration and team decision-making. Others will lean toward transactional leadership, where delivering results is the measure of success. T-cell engaging biologics is a class of novel and promising immune-oncology compounds that leverage the immune system to eradicate cancer. Here, we compared and contrasted a bispecific diabody-Fc format, which displays a relatively short antigen-binding arm distance, with our bispecific IgG platform. By generating diverse panels of antigen-expressing cells where B cell maturation antigen is either tethered to the cell membrane or located to the juxtamembrane region and masked by elongated structural spacer units, we presented a systematic approach to investigate the role of antigen epitope location and molecular formats in immunological synapse formation and cytotoxicity. We demonstrated that diabody-Fc is more potent for antigen epitopes located in the membrane distal region, while bispecific IgG is more efficient for membrane-proximal epitopes. Additionally, we explored other parameters, including receptor density, antigen-binding affinity, and kinetics. Our results show that molecular format and antigen epitope location, which jointly determine the intermembrane distance between target cells and T cells, allow decoupling of cytotoxicity and cytokine release, while antigen-binding affinities appear to be positively correlated with both readouts. Our work offers new insight that could potentially lead to a wider therapeutic window for T-cell engaging biologics in general. Alzahrani, T., Nguyen, T., Ryan, A., Dwairy, A., McCaffrey, J., Yunus, R., et al. (2019). Cardiovascular disease risk factors and myocardial infarction in the transgender population. Circulation: Cardiovascular Quality and Outcomes, 12. https://doi.org/10.1161/circoutcomes.119.005597. Bargou R, Leo E, Zugmaier G, Klinger M, Goebeler M, Knop S, Noppeney R, Viardot A, Hess G, Schuler M, et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science. 2008;321:974–77. doi:10.1126/science.1158545.van de Grift, T. C., Elaut, E., Cerwenka, S. C., Cohen-Kettenis, P. T., & Kreukels, B. P. C. (2018). Surgical satisfaction, quality of life, and their association after gender-affirming surgery: A follow-up study. Journal of Sex and Marital Therapy, 44(2), 138–148. https://doi.org/10.1080/0092623x.2017.1326190. Bigby JA, Perez-Stable E. The Challenge of Understanding and Eliminating Racial and Ethnic Disparities in Health. Journal of General Internal Medicine. 2004; 19(2):201–203. [ PMC free article] [ PubMed] [ Google Scholar]

Nisbett RE, Masuda T. Culture and point of view. Proceedings of the National Academy of Sciences. 2003; 100(19):11163–11170. [ PMC free article] [ PubMed] [ Google Scholar] Bever, L. (2019). Conversion therapy associated with severe psychological distress in transgender people, study says. The Washington Post. Retrieved September 7, 2020 from https://www.washingtonpost.com/health/2019/09/11/conversion-therapy-associated-with-severe-psychological-distress-transgender-people-study-says/.Li, G., Kung, K. T. F., & Hines, M. (2017). Childhood gender-typed behavior and adolescent sexual orientation: A longitudinal population-based study. Developmental Psychology, 53(4), 764–777. https://doi.org/10.1037/dev0000281. Klink, D., Caris, M., Heijboer, A., van Trotsenburg, M., & Rotteveel, J. (2015). Bone mass in young adulthood following gonadotropin-releasing hormone analog treatment and cross-sex hormone treatment in adolescents with gender dysphoria. Journal of Clinical Endocrinology & Metabolism, 100(2), E270–E275. https://doi.org/10.1210/jc.2014-2439.

You may also opt to downgrade to Standard Digital, a robust journalistic offering that fulfils many user’s needs. Compare Standard and Premium Digital here. Huang F, Chung H, Kroenke K, Delucchi K, Spitzer R. Using the Patient Health Questionnaire-9 to Measure Depression among Racially and Ethnically Diverse Primary Care Patients. Journal of General Internal Medicine. 2006; 21(6):547–552. [ PMC free article] [ PubMed] [ Google Scholar] Churcher Clarke, A., & Spiliadis, A. (2019). ‘Taking the lid off the box’: The value of extended clinical assessment for adolescents presenting with gender identity difficulties. Clinical Child Psychology and Psychiatry, 24(2), 338–352. https://doi.org/10.1177/1359104518825288. Provider organizations, such as community mental health centers, need to actively plan to become more responsive to their client’s culture. All employees and associates of a provider organization must have an awareness of the impact of culture on treatment outcomes. This awareness of culture should be reflected in all provider policies and practices related to client engagement and inclusion, needs assessment, case formulation, goal context, treatment intervention, and treatment location. Provider managers should understand that improved cultural awareness does not happen with a simple message to staff that it should happen. This message must be accompanied by structural changes (policies, client engagement strategies, linkages to culturally-based community resources, a diversity advisory committee), as well as operational changes (clinical interventions that are sensitive to other worldviews and patterns of communication among family members). Such structural and operational changes are best accomplished when internal staff and external advisor-stakeholders cooperate to develop explicit work plans that are reviewed by management, and are celebrated by both the organization and the community.Politically, the phrase has come to mean that methods of administration or political beliefs in one country should not necessarily be applied to another.

Hofstede G. Attitudes, values and organizational culture: disentangling the concepts. Organization Studies. 1998; 19(3):477–493. [ Google Scholar] Orne, M. T. (1962). On the social psychology of the psychological experiment: With particular reference to demand characteristics and their implications. American Psychologist, 17, 776–783. Glisson C, Hemmelgarn AL. The effects of organizational climate and interorganizational coordination on the quality of outcomes of children’s service systems. Child Abuse and Neglect. 1998; 22(5):401–421. [ PubMed] [ Google Scholar] Santucci, R. A. (2018). Urethral complications after transgender phalloplasty: Strategies to treat them and minimize their occurrence. Clinical Anatomy, 31(2), 187–190.

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Katz AM, Alegría M. The clinical encounter as local moral world: Shifts of assumptions and transformation in relational context. Social Science & Medicine. 2009; 68(7):1238–1246. [ PMC free article] [ PubMed] [ Google Scholar] Cheung FK, Snowden LR. Community mental health and ethnic minority populations. Community Mental Health Journal. 1990; 26(3):277–291. [ PubMed] [ Google Scholar]