skyn ICELAND Dissolving Microneedle Eye Patches with Hyaluronic Acid & Peptides: to Hydrate, Firm and Smooth Fine Lines (1 Pack)

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Microneedling is the process of inserting very fine, short needles into the skin to renew the surface by increasing cell turnover and releasing proteins. The procedure has been around since the mid-90s and usually takes place at a dermatologist’s office. Many dermatologists use a roller device or a pen-shaped automated microneedling device, both of which contain micro-fine needles ranging in diameter from 0.5 and 2.5 mm. There are also at-home versions, or dermarollers, typically made with microneedles that measure between 0.2 and 1 mm. Peptides: There are some peptides that have been found to be beneficial for skin, although there’s very little independent clinical data. This patch contains a few popular ones: Hong, JY, Ko, EJ, Choi, SY, et al. Efficacy and safety of a novel, soluble microneedle patch for the improvement of facial wrinkle, J Cosmet Dermatol 2018, 17, 235–241. DOI: 10.1111/jocd.12426

Park KY, Kwon HJ, Lee C, et al Efficacy and safety of a new microneedle patch for skin brightening: a randomized, split-face, single-blind study, J Cosmet Dermatol 2017, 16, 382–387. DOI: 10.1111/jocd.12354 Microneedles are extremely small, micro-sized needles designed to penetrate the outer layer of the skin. It is a common cosmetic procedure used to help improve skin imperfections such as wrinkles and acne scarring or just to rejuvenate the skin. Sharma,R.; Sircar,P.; Pachori,R.B.; Bhandary,S.V.; Acharya,U.R. J.Mech.Med.Biol. 2019, 19, No.1940011. doi:10.1142/s0219519419400116A weekly wakeup call for eyes showing signs of chronic stress (crow’s feet, we’re talking to you), skyn ICELAND Dissolving Microneedle Eye Patches are formulated with a whopping 39% regenerative hyaluronic acid—both high and low molecular weight for maximum absorption—plus a potent hexapeptide complex to help combat crepey skin. A total of 20 subjects aged 27 to 58 years were enrolled in the study. The subjects applied magnesium microneedles patches on the under-eye wrinkle area for one to two hours every other night for 12 weeks. sufficient mechanical strength to reach 200 µm penetration depth; MNs were much more efficient than traditional suspension Hyaluronic Acid is a natural substance found in the body that helps keep skin hydrated, lubricated, and youthful. It helps retain moisture and provides a cushioning effect for the skin, making it look plump and smooth. Used in a variety of skincare products, hyaluronic acid helps reduce wrinkles, fine lines, and dryness.

Skaria,E.; Patel,B.A.; Flint,M.S.; Ng,K.W. Anal.Chem.(Washington,DC,U.S.) 2019, 91, 4436–4443. doi:10.1021/acs.analchem.8b04980 Jung,J.H.; Chiang,B.; Grossniklaus,H.E.; Prausnitz,M.R. J.ControlledRelease 2018, 277, 14–22. doi:10.1016/j.jconrel.2018.03.001 Among the ophthalmic preparations, the most commonly used are eye drops [49-51], ointments [52,53], or gels [54,55], containing the drug in a dissolved or suspended form [56,57]. They are applied by medical personnel or by the patient himself to the surface of the eye, to the conjunctival sac, or on the eyelid. Their main disadvantage is the need for frequent dosing, which can be troublesome. Hence, the treatment regimen is rarely followed, leading to a reduction in the effectiveness of the therapy [58,59]. Therefore, apart from designing the vehicle/base composition, drugs are often incorporated into appropriate carriers or introduced into systems whose purpose is to provide the expected concentration in the treated tissue for the desired time period. The most frequently studied and described are liposomes [60,61], micelles [60,62], microparticles [63-65], nanoparticles [66,67], micro- [68,69], and nanoemulsions [70,71]. Unfortunately, it has to be noticed that most technological solutions on the nanoscale are only promising at the laboratory stage. The transfer of such technologies to an industrial scale is often complicated and causes many difficulties [72-74]. Prausnitz, M. R.; Jiang, N.; Edelhauser, H. F. Method for Drug Delivery to Ocular Tissue Using Microneedle. WO2007131050A3, Feb 14, 2008. DeMuth,P.C.; Garcia-Beltran,W.F.; Ai-Ling,M.L.; Hammond,P.T.; Irvine,D.J. Adv.Funct.Mater. 2013, 23, 161–172. doi:10.1002/adfm.201201512Kim YC, Park JH & Prausnitz MR, Microneedles for drug and vaccine delivery (open access), Adv Drug Deliv Rev 2012, 64, 1547-1568. DOI: 10.1016/j.addr.2012.04.005 Gonenc, B.; Chae, J.; Gehlbach, P.; Taylor, R. H.; Iordachita, I. Sensors 2017, 17, 2195. doi:10.3390/s17102195 It’s recommended that you use the Pimple Patches at the first sign of a pimple, and the Plumping Patches twice a week to begin with. My experience with microneedling patches Albadr,A.A.; Tekko,I.A.; Vora,L.K.; Ali,A.A.; Laverty,G.; Donnelly,R.F.; Thakur,R.R.S. DrugDeliveryTransl.Res. 2022, 12, 931–943. doi:10.1007/s13346-021-01032-2

Nieminen,T.; Lehtimäki,T.; Mäenpää,J.; Ropo,A.; Uusitalo,H.; Kähönen,M. Scand.J.Clin.Lab.Invest. 2007, 67, 237–245. doi:10.1080/00365510601034736Hassan,J.; Haigh,C.; Ahmed,T.; Uddin,M.J.; Das,D.B. Pharmaceutics 2022, 14, 1066. doi:10.3390/pharmaceutics14051066 Ding,D.; Kundukad,B.; Somasundar,A.; Vijayan,S.; Khan,S.A.; Doyle,P.S. ACSAppl.BioMater. 2018, 1, 561–571. doi:10.1021/acsabm.8b00041 Any tips for post-treatment? You can apply the Brightening Eye Serum again and follow with the Icelandic Relief Eye Cream to help de-puff and reduce appearance of dark circles.

Lee,Y.; Park,S.; Kim,S.I.; Lee,K.; Ryu,W. Adv.Mater.Technol.(Weinheim,Ger.) 2020, 5, 1901145. doi:10.1002/admt.201901145 Koh,K.J.; Liu,Y.; Lim,S.H.; Loh,X.J.; Kang,L.; Lim,C.Y.; Phua,K.K.L. Sci.Rep. 2018, 8, 11842. doi:10.1038/s41598-018-30290-3 permeation studies on porcine eyeballs showed that due to application of the MN patches the total amount of released dye was close to 18%, whereas from flat patches only 1% was determined after 24 h What I can always see right away is a brightening of the shadows and lightening my dark circles. It’s unbelievable just how much lighter they are. The skin looks so much hydrated which has really helped to reduce the crepiness of my skin and soften the lines.Shastri,D.; Shelat,P.; Shukla,A.; Patel,P. Syst.Rev.Pharm. 2010, 1, 113. doi:10.4103/0975-8453.75042 Verin,P.; Allewaert,R.; Joyaux,J.C.; Piozzi,E.; Koliopoulos,J.; Bloch-Michel,E. Eur.J.Ophthalmol. 2001, 11, 120–125. doi:10.1177/112067210101100203