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Combination products are marketed as comprehensive cold-fighting remedies, but the main benefit is convenience. Sympathomimetic amines: concomitant use of phenylephrine with other sympathomimetic amines can increase the risk of cardiovascular side effects. Paracetamol is thought to relieve pain by reducing the production of prostaglandins in the brain and spinal cord. It works to bring down a fever by affecting an area of the brain that regulates our body temperature (the hypothalamic heat-regulating center). This stops you feeling hot or shivery. Find out more about which painkiller to choose for different types of aches and pains in our full painkillers guide
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The systemic availability is subject to first-pass metabolism and varies with dose between 70% and 90%. The drug is rapidly and widely distributed throughout the body and is eliminated from plasma with a T1 /2 of approximately 2 hours. The major metabolites are glucuronide and sulphate conjugates (>80%) which are excreted in urine. It's fine to take Beechams cold & flu sachets with plain ibuprofen or aspirin (assuming these are appropriate for you). However, don't take them with co-codamol, co-dydramol or Tramacet because these contain paracetamol. Don't be afraid to ask the pharmacist if there's a cheaper generic version of a medicine you're considering, or for advice on the evidence behind certain treatments, as they should be able to help with any queries you have about cold and flu medicines. Asda was also the cheapest place to get both Lemsip and Sudafed capsules. The Sudafed capsules were as cheap at Sainsbury's, and the Lemsip capsules were as cheap at Superdrug and Morrisons, as they were on offer. Care is advised in the administration of paracetamol to patients with severe renal or severe hepatic impairment. The hazard of overdose is greater in those with non-cirrhotic alcoholic liver disease.
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Patients should be advised not to take other paracetamol-containing or other cold, flu or decongestant products concurrently. You could get the same effect more cheaply by taking a painkiller and drinking a cup of tea or coffee, especially as the evidence is weak for the decongestant element (see more on decongestants below). Allergic reactions such as a rash or itching. Stop using this medicine and get medical advice if you think you've had an allergic reaction to it. Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma paracetamol concentration should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of paracetamol, however, the maximum protective effect is obtained up to 8 hours post-ingestion. The effectiveness of the antidote declines sharply after this time. If required the patient should be given intravenous N-acetylcysteine, in line with the established dosage schedule. If vomiting is not a problem, oral methionine may be a suitable alternative for remote areas, outside hospital. Management of patients who present with serious hepatic dysfunction beyond 24h from ingestion should be discussed with the NPIS or a liver unit. Women who are pregnant. (Phenylephrine has blood vessel constricting effects that could restrict blood supply to the placenta, or cause problems for women with a history of pre-eclampsia. Ask your doctor or pharmacist for advice on how to treat cold and flu symptoms during pregnancy.)
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The product should be avoided during lactation unless recommended by a healthcare professional. There are limited data on the use of phenylephrine in lactation.This medicinal product contains 120.74 mg sodium per dose, equivalent to 6 % of the WHO recommended maximum daily intake for sodium. Be aware that you probably won't need all these ingredients for the duration of a common cold. If you aren't feeling congested, for example, you can always switch to a painkiller and cup of coffee instead. Paracetamol overdose may cause liver failure which may require liver transplant or lead to death . Liver damage is possible in adults who have taken 10g or more of paracetamol. Ingestion of 5g or more of paracetamol may lead to liver damage if the patient has risk factors (see below). Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine. Phenylephrine overdose is likely to result in: nervousness, headache, dizziness, insomnia, increased blood pressure, nausea, vomiting, reflex bradycardia, mydriasis, acute angle closure glaucoma (most likely to occur in those with closed angle glaucoma), tachycardia, palpitations, allergic reactions (e.g. rash, urticaria, allergic dermatitis), dysuria, urinary retention (most likely to occur in those with bladder outlet obstruction, such as prostatic hypertrophy).
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What to know about getting a flu jab - who's eligible for a free one, and where's cheapest otherwise There have been reports of blood dyscrasias including thrombocytopenia, leucopenia, pancytopenia, neutropenia and agranulocytosis, but these were not necessarily causally related to paracetamol. a, Is on long term treatment with carbamazepine, phenobarbitone, phenytoin, primidone, rifampicin, St John's Wort or other drugs that induce liver enzymes.If your symptoms persist despite taking this medicine ask your pharmacist for advice. Don't take it continuously for more than seven days without seeing your doctor or pharmacist. Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma paracetamol concentration should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of paracetamol, however, the maximum protective effect is obtained up to 8 hours post-ingestion. The effectiveness of the antidote declines sharply after this time. If required the patient should be given intravenous N-acetylcysteine, in line with the established dosage schedule. If vomiting is not a problem, oral methionine may be a suitable alternative for remote areas, outside hospital. Management of patients who present with serious hepatic dysfunction beyond 24 hours from ingestion should be discussed with the NPIS or a liver unit. Use during breastfeeding should be avoided, unless recommended by a healthcare professional (see section 4.6). Special offers don't always add up to better value, as you may still be able to get the product cheaper elsewhere. Look out for the active ingredients on the front of the box to see if there's a similar version that will work for you and costs less.
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