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I. Eliaz, et al., “The Effect of Modified Citrus Pectin on Urinary Excretion of Toxic Elements,” Phytother. Res. 20(10), 859–864 (2006). Abnormal angiogenesis and diversion of pre-existing blood vessels are crucial in neoplastic as well as inflammatory and fibrotic conditions, as these processes provide the nutrients and oxygen needed to sustain otherwise hypoxic environments 95. Interestingly, the glycome of ECs varies considerably in response to immunosuppressive or hypoxic stimuli, which favour exposure of galectin-specific glycan epitopes 9. Several galectin family members have pro-angiogenic activity as a result of their capacity to bind distinct glycosylated receptors on the EC surface 96. For example, GAL1 interacts with complex N-glycans on vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) and promotes receptor phosphorylation followed by activation of the AKT and ERK1/2 signalling pathways, thus preserving vascularization in tumours that are resistant to anti-VEGF treatment 9 (Fig. 2). These actions link tumour hypoxia to aberrant angiogenesis pathways identified in melanoma as well as lung, prostate and pancreatic adenocarcinoma 9, 78, 97, 98, 99, 100, 101. Likewise, interactions with the transmembrane glycoprotein, neuropilin 1 (NRP1) are essential for GAL1-driven angiogenesis and induction of vascular permeability 102, 103 (Fig. 2). Recently, an alternative mechanism was proposed whereby GAL1 regulates angiogenesis through binding to the mRNAs of angiogenesis-related factors, including VEGF-A, early growth response 1 protein (EGR1) and α 5 laminin 104.
Hopefully, this dietary supplement will ultimately be one that lives up to its promise. In the meantime, we will continue to keep an eye on all this has to offer. Both the green banana and the pectin significantly improved intestinal permeability and also reduced diarrhea [ 13]. Increasing Sepsis Survival When taken at the active dose of 15 grams per day, many people report feeling a significant difference in the following areas: Research in cancer: With powerful antiadhesive, apoptosis-promoting properties, this researched MCP is shown in more than 15 published studies, including three clinical studies, to target numerous rate-limiting steps in cancer, primarily via its ability to inhibit Gal-3. 10–12 N. Tehranian, et al., “Combination Effect of PectaSol and Doxorubicin on Viability, Cell Cycle Arrest and Ppoptosis in DU-145 and LNCaP Prostate Cancer Cell Lines,” Cell Biol. Int. 36(7), 601–610 (2012).But the loss of important minerals may not occur with use of modified citrus pectin, as evidenced by a recent study on urinary excretion of toxic elements in healthy individuals. Of all 49 patients, 22.5% had stabilized cancer and 12.3% were stable for longer than six months. One patient with metastasized prostate cancer had 50% fewer prostate-specific antigen (PSA) in his system after 16 weeks on modified citrus pectin. PSA levels may indicate the likelihood of prostate cancer progression [ 8].
To find out more about MCP treatment and its potential health benefits, we’ll take a closer look at the research we have so far. For best results, take PectaSol at an active dose of 15 grams per day. Active dose (max. level support) is 5 grams three times per day. Maintenance dose (min. level support) is 5 grams one time per day.
GAL1 is upregulated in most tumour tissues and their associated stroma and has been proposed as a biomarker of poor prognosis in breast, colon, lung, prostate adenocarcinoma and melanoma 65. Tumours of the digestive tract and urinary system, as well as thyroid cancer and melanomas, express high levels of GAL3; by contrast, GAL3 expression is downregulated in tumours of the reproductive tract. Subcellular compartmentalization of GAL3 is a crucial factor contributing to its pro- or antitumoural roles. For example, increased GAL3 within the nuclear compartment has been associated with a better outcome among patients with neuroblastoma 66. On the other hand, GAL9 expression can be up- or downregulated in association with neoplastic transformation depending on the specific tumour type 65, 67. As the expression of these lectins can change during tumour progression, they have been proposed as biomarkers for diagnosis, prognosis and/or intervention in various cancer stages 65. If you’re concerned about possible sensitivities to MCP, consult with your practitioner before use, and start with a lower dose to see how your body responds. The Bottom Line on Modified Citrus Pectin The expression and subcellular localization of galectins differ considerably in individual cell types. These properties are dynamically regulated by cell activation, differentiation and anatomical distribution and can undergo dramatic modulation in response to specific pathological conditions 8, 15. Galectins are synthesized as cytosolic proteins and in response to environmental signals can shuttle between the cytosol and the nucleus. They control intracellular processes via specific protein–protein or protein–glycan interactions 45, 46. For example, GAL1 and GAL3 interact with RAS GTPases in the cytoplasm, whereas through binding to Gemin4 (ref. 47) they have a role in spliceosome assembly in the nucleus 48. Moreover, intracellular partners of GAL3 include β-catenin 45 and hnRNPA2B1 (ref. 49) in the nucleus, and Alix, a component of the endosomal sorting complex required for intracellular transport 50, 51. Interestingly, cytosolic galectins might act as ‘danger signal sensors’ that detect abnormal exposure of glycan moieties within the cytosolic compartment 52, 53.
G. Hossein, et al., “Synergistic Effects of PectaSol-C Modified Citrus Pectin an Inhibitor of Galectin-3 and Paclitaxel on Apoptosis of Human SKOV-3 Ovarian Cancer Cells,” Asian Pac. J. Cancer Prev. 14(12), 7561–7568 (2013). The original and only proven effective form of MCP is prepared with a proprietary, non-GMO enzymatic process controlled by pH and heat, which breaks the long chain molecules of the native pectin to produce the correct molecular size and structure of <13 kilodaltons and <5% esterification.
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Within the galectin family, Gal-3 has unique properties. It is a beta-galactoside-binding protein involved in a wide array of biological processes, mainly related to cell cycle, immunity and injury repair. Gal-3 is found in the nucleus, cytoplasm, mitochondrion, fibroblasts, cell surface and extracellular matrix. Circulating Gal-3 levels increase with age, injury and chronic illness. GAL3 expression is upregulated in fibrotic lesions in human subjects 63, and the severity of hepatic and lung fibrosis is reduced in GAL3-deficient mice 33, 142, 143, 144, 145. Thus, GAL3 has emerged as a promising therapeutic target for fibrotic diseases. Mechanistically, GAL3 induces a pro-fibrotic macrophage phenotype by interacting with the neutral amino acid transporter CD98 (ref. 123). Likewise, GAL3-secreting macrophages drive myofibroblast differentiation, which ultimately results in scar formation 146. Moreover, ECs and myofibroblasts upregulate GAL3 expression upon their activation 142, 147, 148; this facilitates EMT, apoptosis, myofibroblast proliferation and enhanced production of fibronectin and other proteins found in the extracellular matrix 149, 150, 151. October 29, 2021 Dr. Michael Ruscio, DC is a clinician, Naturopathic Practitioner, clinical researcher, author, and adjunct professor at the University of Bridgeport. His work has been published in peer-reviewed medical journals and he speaks at conferences around the globe. Modified Citrus Pectin Benefits for Heavy Metal Detox and Beyond Plant-derived polysaccharides have also been proposed as therapeutics for liver, kidney and lung fibrosis, mainly via mechanisms that involve inhibition of GAL3 (refs. 142, 146). Inhibition of GAL3 with belapectin ( 18, Fig. 4) and Davanat ( 19, Fig. 4) was first evaluated in a toxin-induced model of liver fibrosis 232. Intraperitoneal administration of these polysaccharides resulted in decreased collagen content, attenuated liver fibrosis, diminished cirrhosis and a reduced percentage of GAL3-expressing macrophages 232. These two inhibitors were also tested in a murine model of NASH 233. Intravenous administration of belapectin resulted in a substantial reduction in collagen deposition, hepatocellular damage, NASH activity and fibrosis
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