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Ultimately, no firm conclusions can be made on the effectiveness of glucosamine, chondroitin, or the two combined as a treatment for osteoarthritic pain or stiffness. Due to the large inconsistency in results and quality of available research, continued research is needed. Summary
The case for these supplements protecting joint health or preventing arthritis from worsening is similarly weak.Chondroitin and glucosamine is a combination product that has been used in alternative medicine as a possibly effective aid in treating osteoarthritis pain.
These arthritis supplements are generally well-tolerated. However, side effects can occur. The most commonly reported side effects of glucosamine and chondroitin include: It is not certain whether chondroitin, glucosamine, and MSM is effective in treating any medical condition. Medicinal use of this product has not been approved by the FDA. This product should not be used in place of medication prescribed for you by your doctor. Another concern is drug interactions, which may be a problem with any combination of medications. For example, chondroitin may interact with blood thinners such as warfarin, so the combination could increase the risk of bleeding. The effects of these supplements on a growing child or developing baby are not yet known. For that reason, glucosamine and chondroitin are not recommended for children, women who are pregnant, women who are nursing, and women who could become pregnant. What Are the Side Effects of Glucosamine and Chondroitin? Food supplements must not be used as a substitute for a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, taking any medications or under medical supervision, please consult a doctor or healthcare professional before use. Discontinue use and consult a doctor if adverse reactions occur. Keep out of reach of children. Do not use if seal under cap is broken or missing. Consult a doctor before use if you have or have had diabetes or hypoglycemia. Not intended for use by persons under the age of 18.
MSM is a naturally occurring compound and its effects on inflammation have been extensively studied. Vasiliadis HS, Tsikopoulos K. Glucosamine and chondroitin for the treatment of osteoarthritis. World J Orthop. 2017;8(1):1-11. doi:10.5312/wjo.v8.i1.1 Similarly, a 2015 sponsored study showed that combining 1,500 mg of glucosamine hydrochloride with 1,200 mg of chondroitin sulfate effectively reduced knee osteoarthritis pain, stiffness, and swelling compared with 200 mg of the osteoarthritis NSAID celecoxib ( 15). If you are thinking about taking a glucosamine supplement, it’s essential to be aware of its side effects. On the whole, it’s believed to be safe for most people and side effects tend to be rare. 13 If you do notice any unwanted side effects, stop taking glucosamine and talk to your doctor if you’re concerned.