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AREDS2 VISION DEFENDER AMD Supplement: Lutein, Zeaxanthin, Zinc, Vitamin E – AREDS 2 Eye Vitamins, Minerals, Nutrients for Eyes. 3 Months Supply (90 tablets) One-A-Day Vegan Eye Supplement. Made in UK

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Dry AMD is the more common type of AMD. It develops very slowly and causes a gradual change in your central vision. Dry AMD usually takes a long time – often years, to get to its final stage. At its final stage, dry AMD causes a blank patch in the centre of your vision in both of your eyes. It doesn’t affect your peripheral (side) vision, so it never leads to total blindness.

While we believe that taking supplements containing lutein may be beneficial to eye health, we do not endorse any brand. Smoking Trust Altacor with your sight - Altacor was formed in 2006 by two co-founders and has grown into a reputable and respected company within the ophthalmic industry and now distributes award winning ophthalmic products across the globe. Many people with AMD have drusen. These alone do not cause vision loss. But when drusen grow in size or number, you are at risk for getting early or intermediate AMD. There are not always symptoms with these stages of AMD, though people with intermediate AMD might start to notice a blurred spot in their central vision. This specific nutrient combination has been formulated to match the supplements used in Phase 2 of the Age Related Eye Disease Study (AREDS2). The AREDS studies are large, scientific trials conducted by the National Eye Institute in the United States, which looked at the role of dietary supplements in Age Related Macular Degeneration. Seddon JM, Rosner B, Sperduto RD, et al. Dietary fat and risk for advanced age-related macular degeneration. Arch Ophthalmol. 2001;119(8):1191-9. doi:10.1001/archopht.119.8.1191.Also be aware of supplements containing only bilberries and not pine bark extract – bilberry supplements are common, but those combined with pine bark extract are uncommon. The results of AREDS 2 showed a similar reduction in risk of progression to late AMD as in the first AREDS formula. Beta-carotene supplements have been found to increase the risk of lung cancer in smokers and people who have previously smoked. Results of AREDS2 Be aware of:Supplements containing ALA (another omega-3 fatty acid) instead of DHA/EPA. ALA is found mainly in plant oils such as flaxseed, and only very small amounts are converted by the body to useful EPA and then to DHA. Practically, this means DHA/EPA needs to be consumed directly from food or supplements. Note that studies of health benefits of omega-3 generally involve using DHA/EPA omega-3 supplements (not ALA omega-3). Mares-Perlman JA, Fisher AI, et al. Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey. Am J Epidemiol. 2001 Mar 1;153(5):424-32. doi: 10.1093/aje/153.5.424. https://pubmed.ncbi.nlm.nih.gov/11226974/

Chew EY, Clemons T, Sangiovanni JP, et al. The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). Ophthalmology. 2012;119(11):2282-9. doi:10.1016/j.ophtha.2012.05.027Not all supplements have sound clinical research to support their claims. Beware of any which claim to 'cure' macular degeneration. Multiple studies have shown omega-3 (DHA/EPA) supplements beneficial in reducing the prevalence and severity of dry eye disease [1] [2]. However, other studies have not found this [3]. It is worth noting that conflicting studies regarding omega-3 in other areas of health also exist, especially in the heavily researched area of cardiovascular disease. What to make of these conflicting studies? Oxidation may be a factor. DHA/EPA is commonly derived from fish oil, which is highly susceptible to oxidation. No trials have reported the oxidative state of the trial oil which would question the validity of the results and conclusions of these trials [4]. Adding antioxidants (such as vitamin E) reduce (but do not prevent) oxidation [4] [5]. Anecdotally, many people have said taking an omega-3 supplement has helped their dry eyes. Therefore it’s worth considering an omega-3 (DHA/EPA) supplement for dry eyes. The recommended dietary allowance (RDA) of vitamin E for adults over 14 years old is 22.4 IU; but it is not the maximum dose. Rather, it is the dose that nutrition experts have decided is sufficient for most people to remain healthy. The AREDS formula contains 400 IU to provide vitamin E beyond usual dietary intake. Some scientists believe that another macular carotenoid, meso-zeaxanthin, is also important for macular health. It is made by the body from lutein. It was not tested in the AREDS trials and not all scientists agree on its significance. More research is needed in this area. Diet is important because certain nutrients protect the body from damaging substances called oxidants.

New blood vessel growth is medically known as “neovascularisation”. Neovascularisation can cause a lot of damage to your macula and can eventually lead to scarring. Both the new blood vessels and the scarring cause damage to your central vision and may lead to a blank patch in the centre of your sight.Based on the results of AREDS and AREDS2 and concerns about the risk of beta-carotene for smokers, the current recommended daily formula to slow down the progression of AMD in people already diagnosed is: AREDS found that people diagnosed as being at medium or high risk of progression of AMD, who took the “AREDS formula” used on the trial, reduced their progression by 25 per cent. However, the beneficial effect of taking the supplement was not significant in those with a diagnosis of early-stage low risk AMD.

Eye Disease Case-Control Study Group. Antioxidant status and neovascular age-related macular degeneration. Arch Ophthalmol. 1993 Jan;111(1):104-9. doi: 10.1001/archopht.1993.01090010108035. https://pubmed.ncbi.nlm.nih.gov/7678730/ A healthy diet full of fruits and vegetables is thought to be beneficial in keeping our eyes as heathy as possible. Fruit and vegetables are an important source of vitamins and minerals. The NHS advises we should eat at least five portions of a variety of fruit and vegetables every day.TRUST AND BENEFIT FROM THE SPECIALISTS – The trusted Vision Defender range of eye vision supplements has been specially developed by qualified health care professionals to improve the health and vision of your eyes. Our Chief Pharmacist and Co-Founder Keith specialises in eye nutrition and has written a book: “Help! What Vitamins Should I Take for My Eyes?” Our eyesight is precious and important in everything we do - continue to do all the things you love with Vision Defender. Your optometrist or ophthalmologist might say you have early AMD if you have larger drusen in one or both your eyes. Other changes at the macula, as well as drusen, will indicate whether your early AMD has a low, medium, or high risk of progression (worsening). At present the strongest evidence about which vitamin formula to take comes from AREDS (2001) and AREDS2 (2012), two large-scale clinical trials carried out in the United States. This means that at present these supplements cannot be clearly recommended to everyone with AMD. More research is needed to determine if antioxidant and other supplements marketed for AMD are worth taking. While it is important to eat a wide range of foods, the vegetables that have the highest amount of lutein are:

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