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The In-Competition period starts at 11:59 pm on the day before the competition through to the end of the competition and the sample collection process related to the competition. Bupropion, caffeine, nicotine, phenylephrine, phenylpropanolamine, pipradrol, and synephrine: These substances are included in the 2023 Monitoring Program and are not considered Prohibited Substances. Activators of the AMP-activated protein kinase (AMPK), e.g. AICAR, SR9009; and peroxisome proliferator-activated receptor delta (PPARδ) agonists, e.g. 2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methylthio) phenoxy) acetic acid (GW1516, GW501516)

High school sport-related drug use rumours to have commenced – a physician in Texas allegedly administered Dianabol to the high school football team The idea is to make a "slide" for the cross, so you steer the power away instead of absorbing it with your body Prohibited substances in classes S4.1 and S4.2 are Specified Substances. Those in classes S4.3 and S4.4 are non -Specified Substances. Ciba Pharmaceutical Company released Dianabol (methandrostenolone) and US sports doctor Dr John Ziegler begins experimenting with testosterone for the US weightlifting team. Efficacy of these drugs apparently spread by word of mouth during the early 1960s to other strength-intensive sports, from field events to football Three cyclists fail the mandatory health test just prior to commencement of the 2000 Tour de France – they were not permitted to start because they had a haematocrit >50%

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Boxer B's palm meets the jab with a bit of added force (from B), pushing the jab to the left side of their head In males suppress the hypothalamic–pituitary–testicular axis (HPT) reducing the concentrations of the gonadotrophic hormones, luteinising hormone (LH) and follicle-stimulating hormone (FSH), which reduces the concentrations of circulating endogenous testosterone Lance Armstrong admits to doping during his television interview with ‘Oprah’ and was subsequently stripped of his seven Tour de France medals

ASDA (now ASADA) became the first National Anti-Doping Organisation to establish a domestic blood-testing programme Analytical – immunoassay. The C3 epimer of testosterone will cross react in testosterone immunoassays and it is structurally nearly identical possessing the same number of carbon, oxygen and hydrogen atoms Analytical – mass spectrometry. Need to ensure chromatographic separation as this compound is the C3 epimer of testosterone and shares the same molecular weight and ion transitions Two tests developed by British scientists to detect for anabolic steroids. One test is by radioimmunoassay and the other is by gas chromatography couples with mass spectrometry. The IOC decides to adopt both tests in tandem to ensure accuracy. These assays do not detect the use of testosterone

References

Inhaled salbutamol: maximum 1600 micrograms over 24 hours in divided doses not to exceed 600 micrograms over 8 hours starting from any dose Amphetamines identified as a central nervous system stimulant and became available via prescription in 1937

All prohibited substances in this class are Specified Substances except those in S6.A, which are non- Specified Substances.

Methods for literature review

As you raise your arm, your elbow comes at a 90º angle with your body and moves to the center, in front of your face/chin AAS introduced as a banned class of compounds by the IOC following the positive screening results of the 1974 Commonwealth Games As an example, a single daily dose of 3 x 60 mg tablets would be a supratherapeutic dose that may lead to an Adverse Analytical Finding .

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