Optibac Probiotics Bifido & Fibre - Vegan Digestive Probiotic Supplement with FOS Fibre to Maintain Regularity & 25 Billion Bacterial Cultures - 30 Sachets

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As some properties & benefits of probiotics may be strain-specific, this database provides even more detailed information at strain level. Read more about the strains that we have included from this genus below.

O’Mahony C. (2008), ‘Commensal-induced regulatory T cells mediate protection against pathogen-stimulated NF-kappaB activation’, PLoS Pathog. 4(8):e1000112.Pokusaeva, K., Fitzgerald, G. F. & van Sinderen, D. Carbohydrate metabolism in Bifidobacteria. Genes & nutrition 6, 285–306, doi: 10.1007/s12263-010-0206-6 (2011). A study by Charbonneau, D. et al (2013) found that after 8 weeks of oral supplementation with B. infantis35624, the strain was recovered from stool samples, suggesting that the strain reaches the gut alive. Faecal levels of Bifidobacterium infantis35624 were found to decline and return to baseline levels once oral supplementation ceased, indicating its transiency. Bifidobacterium infantis35624 and Irritable Bowel Syndrome (IBS)

Human Microbiome Project, C. Structure, function and diversity of the healthy human microbiome. Nature 486, 207–214, doi: 10.1038/nature11234 (2012). Andresen V, Gschossmann J, Layer P. Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial. Lancet Gastroenterol Hepatol. 2020;5(7):658-666. View abstract. Groeger, D. (2013), ‘ Bifidobacterium infantis35624 modulates host inflammatory processes beyond the gut’, Gut Microbes. 4 (4): 325-339. Sommerfield D. et al (2003), ‘Influence of Bifidobacterium infantisfeeding on secretagogue response and gut barrier function in rats recovering from colitis’, Gastroenterology,124:A311

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O’Mahony L, et al (2004), ‘Mechanism of probiotic/commensal mediated protection against invasive Salmonellainfection’, Gastroenterology.2004:126

Marino, K. et al. Method for milk oligosaccharide profiling by 2-aminobenzamide labeling and hydrophilic interaction chromatography. Glycobiology 21, 1317–1330, doi: 10.1093/glycob/cwr067 (2011). More clinical trials on human subjects are needed to evaluate the value of B. bifidum on the immune system. Eczema in infants Lievin V, Peiffer I, Hudault S, et al. Bifidobacterium strains from resident infant human gastrointestinal microflora exert antimicrobial activity. Gut 2000;47:646-52. View abstract. Namba, K., Hatano, M., Yaeshima, T., Takase, M., and Suzuki, K. Effects of Bifidobacterium longum BB536 administration on influenza infection, influenza vaccine antibody titer, and cell-mediated immunity in the elderly. Biosci.Biotechnol.Biochem. 2010;74(5):939-945. View abstract. Odamaki, T., Xiao, J. Z., Iwabuchi, N., Sakamoto, M., Takahashi, N., Kondo, S., Iwatsuki, K., Kokubo, S., Togashi, H., Enomoto, T., and Benno, Y. Fluctuation of fecal microbiota in individuals with Japanese cedar pollinosis during the pollen season and influence of probiotic intake. J Investig.Allergol.Clin.Immunol. 2007;17(2):92-100. View abstract.

Chen K-S, et al (2005), ‘Oral administration with a unique probiotic strain, Bifidobacterium infantis35624, to IBS subjects normalizes their systemic immunological imbalance in cytokine profile toward healthy subjects’, Can J Gastroenterol. 19 (Suppl SB):R.1112. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7):2234-2248. View abstract. Turroni, F. et al. Exploring the diversity of the bifidobacterial population in the human intestinal tract. Applied and environmental microbiology 75, 1534–1545, doi: 10.1128/AEM.02216-08 (2009). As with many other strains in this database, this bacterial strain has been researched to assess its potential benefits for the relief of Irritable Bowel Syndrome (IBS) and the associated symptoms. The following studies suggest that it may do so because it has an anti-inflammatory effect in the body. It is important to note that this strain is also known by a few different names. This strain has actually recently undergone genome sequencing and whereas it was known beforehand as Bifidobacterium longum subsp. infantis35624, the genome sequencing has actually caused it to be reclassified as Bifibobacterium longum subsp. longum35634. Strictly speaking, therefore, this strain should come under the longum species however it is still much better known and commercially sold as an infantis strain, and it has been kept as such for the purpose of this Probiotics Database. This strain is also commercially known as Bifantis ®(Altmann F, et al. 2016). Bifidobacterium infantis35624 – Safety and Survival

Ciprandi G, et al. (2022) The Probiotics in Pediatric Asthma Management (PROPAM) study. Ann Allergy Asthma Immunol. 129(1):111-113. Soh, S. E., Aw, M., Gerez, I., Chong, Y. S., Rauff, M., Ng, Y. P., Wong, H. B., Pai, N., Lee, B. W., and Shek, L. P. Probiotic supplementation in the first 6 months of life in at risk Asian infants--effects on eczema and atopic sensitization at the age of 1 year. Clin.Exp.Allergy 2009;39(4):571-578. View abstract. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. View abstract. Multiple research studies indicate that B. bifidum is helpful in the following areas. Symptoms of IBS Firmansyah, A., Dwipoerwantoro, P. G., Kadim, M., Alatas, S., Conus, N., Lestarina, L., Bouisset, F., and Steenhout, P. Improved growth of toddlers fed a milk containing synbiotics. Asia Pac.J Clin.Nutr. 2011;20(1):69-76. View abstract.Moludi J, Khedmatgozar H, Saiedi S, Razmi H, Alizadeh M, Ebrahimi B. Probiotic supplementation improves clinical outcomes and quality of life indicators in patients with plaque psoriasis: A randomized double-blind clinical trial. Clin Nutr ESPEN 2021;46:33-39. View abstract. Das RR.Singh M, Shafiq N. Probiotics in Treatment of Allergic Rhinitis. World Allergy Organization Journal 2010;3(9):239-244. Al Faleh K, Anabrees J. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev. 2014;(4):CD005496. View abstract. Sibartie S. et al (2009), ‘Modulation of pathogen-induced CCL20 secretion from HT-29 human intestinal epithelial cells by commensal bacteria’, BMC Immunol., 10:54.