Liposomal Luteolin Capsules 500mg, Maximum Absorption, High Dose Flavonoid, Antioxidant Supplement, Soy-Free, Glute-Free, Non-GMO

Product Information

Specially designed for ease of use, these softgels are easy to swallow, eliminating concerns about taking larger capsules. Nazari QA, Kume T, Takada-Takatori Y, Izumi Y, Akaike A. Protective effect of luteolin on an oxidative-stress model induced by microinjection of sodium nitroprusside in mice. J Pharmacol Sci. 2013;122(2):109–17. Reportedly, the autophagy related gene Beclin 1 (BECN1), which plays an important role in the formation of phagophore and tumor suppression, is found to deplete in the human ovarian, breast, prostate cancers, as well as hepatocellular carcinoma and squamous-cell carcinomas. The same has been ascertained in tumor animal models and cancer-cell lines where a downregulation of BECN1 manifests a marked reduction in autophagy followed by enhanced cell proliferation. In the plants, the flavonoid often stays in the glycosylated form. However, when humans use them, the glycoside is hydrolyzed, which results in freeing the Luteolin, thus helping in the absorption process. What makes this flavonoid unique is that it is heat stable. The treatment of cancer cells with genetically modified autophagy-related 5 siRNA caused a marked reduction in luteolin-triggered sensitization effect on TRAIL. Pre-treatment of cells with c-Jun N-terminal kinase (JNK) inhibitor SP600125 caused a remarkable inhibition of luteolin-instigated surge of the expression of DR5, which suggests the relation between promotion of DR5 expression by JNK activation [ 32].

Potočnjak I, Šimić L, Gobin I, Vukelić I, Domitrović R. Antitumor activity of luteolin in human colon cancer SW620 cells is mediated by the ERK/FOXO3a signaling pathway. Toxicol In Vitro. 2020;66:104852. Ulmubra prides itself on top-notch quality, using all-natural materials and ensuring a safe, effective supplement. In case you were wondering w hat food is highest in luteolin, look no further. This purple leafy vegetable is one of the best sources of luteolin, making it a good option to use as a base for salads or even to substitute for wraps and tortillas. “Its leaves resemble little boats, so I love to make healthy tacos by stuffing a radicchio leaf with other chopped veggies, avocado, and a clean protein, seasoned with cumin and oregano and a burst of freshly squeezed lime,” Dr. Naidoo shares. Taco Tuesday with a side of brain-boosting, heart-healthy benefits, anyone? 3. Green bell peppers aSquared Nutrition’s dedication to quality shines through as this Luteolin supplement is crafted with all-natural ingredients, is non-GMO, vegan-friendly, and gluten-free, catering to diverse dietary preferences and needs.Estrogens are hormones involved in the proliferation and differentiation of their target cells. In response to estrogens, the estrogen receptor (ER) is activated to stimulate DNA synthesis and cell proliferation [ 36]. Flavonoids are naturally occurring phytoestrogens because they can bind to ERs and activate their signaling pathways [ 37- 39]. Because luteolin possesses potent estrogenic activity at low concentrations, it could be a useful agent for hormone replacement therapy [ 40]. Luteolin is further known to raise the level of reduced glutathione and upregulated the expression of glutathione synthetase which is a potent antioxidant [ 8] (Furthermore, it has been observed that luteolin induces apoptosis in human colon cancer cells by activating mitogen-activated protein kinase signaling pathway that plays an important role in programmed cell death [ 9]. In vivo experiments on animal models with diethylnitrosamine-induced liver cancer indicated amelioration in the levels of enzymatic oxidants such as catalase, superoxide dismutase; marker enzymes such as alanine/ aspartate transaminases; α-fetoprotein; and accumulation of lipid peroxides in liver tissues and plasma [ 10]. Kang KA, Piao MJ, Ryu YS, Hyun YJ, Park JE, Shilnikova K, Zhen AX, Kang HK, Koh YS, Jeong YJ, et al. Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells. Int J Oncol. 2017;51(4):1169–78.

Yao Q, Luo Y, Sun L, Wang H, Li W. Luteolin suppressed growth of colon tumor via inflammation, oxidative stress, and NLRP3/IL-1β signal axis. Pharmacognosy Magazine. 2022;18(78):494–501. Yan M, Liu Z, Yang H, Li C, Chen H, Liu Y, Zhao M, Zhu Y. Luteolin decreases the UVA–induced autophagy of human skin fibroblasts by scavenging ROS. Mol Med Rep. 2016;14(3):1986–92. Huang L, Jin K, Lan H. Luteolin inhibits cell cycle progression and induces apoptosis of breast cancer cells through downregulation of human telomerase reverse transcriptase. Oncol Lett. 2019;17(4):3842–50. How the anti- or pro-oxidant effects of luteolin ensue has not been well determined. It is believed that flavonoids could behave as antioxidants or pro-oxidants, depending on the concentration and the source of the free radicals [ 32]. Also, the context and microenvironment of the cell may be important determinants of the outcome of luteolin-induced effects on cellular redox status. For example, the antioxidant activity of luteolin is dependent on Cu, V, and Cd ions in the cells. Changes in the Fe ion concentrations dramatically impact the effect of luteolin's redox-regulating activities. With low Fe ion concentrations (< 50 μM), luteolin behaves as an antioxidant while high Fe concentrations (>100 μM) induce luteolin's pro-oxidative effect [ 33]. Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, MalaysiaNazim UM, Park SY. Luteolin sensitizes human liver cancer cells to TRAIL–induced apoptosis via autophagy and JNK–mediated death receptor 5 upregulation. Int J Oncol. 2019;54(2):665–72. Jiang ZB, Wang WJ, Xu C, Xie YJ, Wang XR, Zhang YZ, Huang JM, Huang M, Xie C, Liu P, et al. Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer. Cancer Lett. 2021;515:36–48. Upon exposure to different ultraviolet (UV-A) radiations, the human skin fibroblasts exhibit autophagy and a burst release of ROS. Incubation with micromolar concentration of luteolin is known to protect human skin fibroblasts from ultraviolet (UV-A) radiation by decreased autophagy as ascertained by fluorescence and transmission electron microscopy. The ROS levels also lowered as indicated by flow cytometry. Furthermore, the treatment with luteolin led to downregulation of the expression of hypoxia-inducible factor-1α and autophagy-associated proteins, Beclin 1, and LC3 in UV-A irradiated human skin fibroblasts as indicated by western blotting assay [ 14].

Wu HT, Lin J, Liu YE, Chen HF, Hsu KW, Lin SH, Peng KY, Lin KJ, Hsieh CC, Chen DR. Luteolin suppresses androgen receptor-positive triple-negative breast cancer cell proliferation and metastasis by epigenetic regulation of MMP9 expression via the AKT/mTOR signaling pathway. Phytomedicine. 2021;81:153437. Autophagy has been identified as a potential approach for limiting the proliferation and viability of cancer cells. Autophagy is a catabolic process that provides energy during starvation. This energy is derived from the degradation of aged cells and organelles, in addition to the toxic cellular components. Autophagy begins with the disruption of mitochondria and various organelles in cytoplasm. The main role of autophagy is to maintain homeostasis of eukaryotic cells during abiotic and biotic stress. The cellular mechanism of autophagy includes the transferring of damaged cells and organelles and deleterious proteins into lysosomes for the onset of their degradation. The simple end products of degradation, such as amino acids are eventually recycled in the cells. As discussed above, ER induces proliferation in several types of cancer cells [ 5]. Luteolin suppresses proliferation of prostate and breast cancer cells in both an androgen-dependent and -independent manner, suggesting that luteolin's anti-estrogen activity may at least partly contribute to its anti-proliferation effect[ 38, 44, 75]. Similar observations were also made in thyroid carcinoma cell lines bearing the ER [ 93]. Further experiments suppressing the expression and function of the ER are needed to confirm the role of ER-mediated signaling in luteolin-induced anti-proliferation in ER-responsive cancer cells. It’s worth mentioning that the majority of people who take luteolin supplements do not experience any significant side effects.Luteolin treatment reportedly increased the number of intracellular autophagosomes, as indicated by an increased expression of Beclin 1, and conversion of LC3B-I to LC3B-II in hepatocellular carcinoma SMMC-7721 cells. These events suggest the onset of autophagy in cancer cells followed by their exposure to luteolin which was validated by a reduction in luteolin-induced autophagy in the presence of autophagy inhibitor chloroquine. However, the effect of autophagy was only partial as cell cycle arrest and induction of apoptosis were also noticed as contributing factors [ 31]. Lim DY, Cho HJ, Kim J, Nho CW, Lee KW, Park JH. Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells. BMC Gastroenterol. 2012;12:9.