Devil's Claw Gel 98% Extra Strong, 100 ml, Made in Italy for Massage to Joints and Muscles, Natural Formula and Dermatologically Tested on Sensitive Skin - Dulàc Pharma

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More high-quality studies are needed, but current research suggests that devil’s claw may be effective at reducing pain associated with osteoarthritis. Schulze-Tanzil, G., Hansen, C., and Shakibaei, M. [Effect of a Harpagophytum procumbens DC extract on matrix metalloproteinases in human chondrocytes in vitro]. Arzneimittelforschung. 2004;54:213-220. View abstract. Erdos, A., Fontaine, R., Friehe, H., Durand, R., and Poppinghaus, T. [Contribution to the pharmacology and toxicology of different extracts as well as the harpagosid from Harpagophytum procumbens DC]. Planta Med 1978;34:97-108. View abstract. Lanhers MC, Fleurentin J, Mortier F, et al. Anti-inflammatory and analgesic effects of an aqueous extract of Harpagophytum procumbens. Planta Med 1992;58:117-23 . View abstract.

Keep in mind that certain conditions, such as heart disease, diabetes, kidney stones and stomach ulcers, may increase your risk of adverse effects when taking devil’s claw. It’s caused by a buildup of uric acid in the blood, which is formed when purines — compounds found in certain foods — break down ( 12).Ameye, L. G. and Chee, W. S. Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence. Arthritis Res Ther 2006;8:R127. View abstract. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Similarly, a 2-month study in 42 individuals with chronic osteoarthritis found that supplementing daily with devil’s claw in combination with turmeric and bromelain, which are thought to have anti-inflammatory effects as well, reduced pain by an average 46% ( 18). Summary Stomach ulcers: Production of acid in the stomach can increase with the use of devil’s claw, which may aggravate peptic ulcers. When applied to the skin: There isn't enough reliable information to know if devil's claw is safe or what the side effects might be.Costa De Pasquale R, Busa G, et al. A drug used in traditional medicine: Harpagophytum procumbens DC. III. Effects on hyperkinetic ventricular arrhythmias by reperfusion. J Ethnopharmacol 1985;13:193-9 . View abstract. Also, some researchers suggest it may reduce uric acid, though the scientific evidence is limited. In one study, high doses of devil’s claw decreased uric acid levels in mice ( 21, 22). This review reported five RCTs dating from 1980 into the use of devil’s claw for osteoarthritis of the hip or the knee. Zegota Z, Gozdzik J, Glogowska-Szelag J. Prospective, multicenter evaluation of a polyherbal supplement alongside standard-of-care treatment for mild knee osteoarthritis. Adv Orthop. 2021;2021:5589597. View abstract. Devil's claw is an herb also known as Garra del Diablo, Grapple Plant, Griffe du Diable, Harpagophyti Radix, Harpagophytum, Harpagophytum procumbens, Harpagophytum zeyheri, Racine de Griffe du Diable, Racine de Windhoek, Teufelskrallenwurzel, Uncaria procumbens, or Wood Spider.