Thorne Curcumin Phytosome 500 mg (Meriva) - 120 Capsules - 60 Servings

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Twelve healthy human volunteers participated in a double-blinded, cross-over study. The plasma concentrations of the individual curcuminoids that are present in turmeric (namely curcumin, demethoxycurcumin, and bisdemethoxycurcumin) were determined at baseline and at various intervals after oral administration over a 12-h period. Results Abe Y, Hashimoto S, Horie T (1999) Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacol Res Off J Italian Pharmacol Soc 39(1):41–47. doi: 10.1006/phrs.1998.0404 Ramaholimihaso T, et al. (2020). Curcumin in depression: Potential mechanisms of action and current evidence — a narrative review. To mitigate potential diarrhea associated with curcumin, be sure to administer it after a large meal and/or consider reducing your dosage. The combination of post-meal ingestion, as well as dosage reduction, may be an effective strategy for preventing curcumin-induced diarrhea. Also keep in mind that sometimes it may take the body a few days to adapt to a newly introduced supplement. Yellowing of skin, stool, sweat: Those supplementing with curcumin have reported yellowing of the skin, stool, sweat, and/or fingernails following curcumin supplementation. In some cases, the yellow sweats associated with curcumin were significant enough to stain bed sheets, towels, etc. Obviously yellowing of the skin could be a sign of jaundice (so get this ruled out), but if you’re taking curcumin and notice everything is turning yellow, you’re likely not alone.

Schiborr C, et al. (2014). The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes. In some cases, the flushing may be accompanied by changes in perceived facial temperature such as hot flashes (warmth) and/or chills. If you discontinue curcumin and notice that the facial flushing subsides, realize that curcumin was likely the culprit. To cope with this side effect, you could consider testing a different brand (without additives) and/or adjust (reduce) your dose. If the facial flushing persists, you may simply need to accept that you don’t tolerate curcumin supplements.

Curcumin Phytosome® Power Complex

Zielińska A, et al. (2020). Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects. It’s also naturally derived and associated with few adverse effects, compared with over-the-counter anti-inflammatory drugs. Ammon HP, Wahl MA (1991) Pharmacology of Curcuma longa. Planta Med 57(1):1–7. doi: 10.1055/s-2006-960004 Then I was feeling better but still had some tummy pain and itching. Started taking supplements again, then about in 8 days the chills and above symptoms started again. My ND who has me taking the Curcumin did not even think of it when I came to see him just two days ago. I found this article and everything became clear! Wahlstrom B, Blennow G (1978) A study on the fate of curcumin in the rat. Acta Pharmacol Toxicol (Copenh) 43(2):86–92

Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Were the side effects severe enough as to make you discontinue curcumin supplementation? Realize that despite emerging evidence suggestive of curcumin’s therapeutic properties, no supplement should be considered utopian or a “magic bullet.” Always listen to your body regardless of what the literature suggests – if you don’t react well to curcumin, it may be a sign to avoid taking it. If you know of any effective side effect mitigation strategies (besides those mentioned in the article), feel free to share them in your comment. Related Posts:DiSilvestro RA, Joseph E, Zhao S, Bomser J (2012) Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J 11:79. doi: 10.1186/1475-2891-11-79 Furthermore, it should be mentioned that among those with medical conditions such as GERD (gastroesophageal reflux disease), curcumin can exacerbate symptoms. If you have been diagnosed with GERD and are taking curcumin, be cognizant of your reaction; if symptoms worsen, the curcumin is likely to blame. To reduce the likelihood of a stomach ache while taking curcumin, avoid taking high doses and be sure to only take it after a meal. N-acetylcysteine (NAC), a precursor to the major antioxidant glutathione (Demedts et al., 2005), was a popular treatment option in the early 2000’s due to significant evidence demonstrating a decrease in oxidative stress burden in patients with lung fibrosis (Demedts et al., 2005; Behr et al., 1997; Meyer et al., 1994). However, in clinical trials, a Discontinuation: If you’ve made numerous changes to your dosage, have tried other brands of curcumin, have ruled out potential interactions, etc. – and you’re still experiencing side effects – it may be time to discontinue treatment. Let’s face it, not all people tolerate the same supplements and drugs equally. You may happen to be a rare (canary-in-the-coalmine) individual that is allergic to and/or simply fails to tolerate curcumin supplementation. In this case, discontinuation may be the only logical option. Idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung disease. Characterized by the overabundance of a highly active fibroblast population (Amara et al., 2010; Strieter & Mehrad, 2009), this fatal lung disease claims the lives of an estimated 41,000–82,000 people annually in Europe and the United States (Hutchinson et al., 2014). This is of particular concern for the world’s aging population as the incidence increases significantly with age (Raghu et al., 2006). The importance of this for developed countries cannot be overstated as the elderly population is expected to double over the next 25 years (Mora et al., 2017). Currently, a number of drugs are at various stages of development, but only two drugs have received FDA approval for the treatment of IPF (Mora et al., 2017).

In extreme cases, users have reported blisters along with the rash. It is unclear as to whether these blisters resulted directly from the curcumin, or whether they were a result of excessive skin scratching by the user. Obviously if you have a severe skin rash, it is imperative to seek immediate medical help as to rule out other potential causes and ensure your own safety. I thought this would be easier because the Curcumin badly stained my wash bowl every time I spat it out, and it was difficult to remove without bleach. I did this for two days only and after the first day I experienced the most excruciating stomach pains that came continuously like waves, and I began vomiting like there was no tomorrow. Not realising it was the Curcumin that was causing this effect, I continued for a second day when I experienced even more stomach pain and more vomiting.Holder GM, Plummer JL, Ryan AJ (1978) The metabolism and excretion of curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in the rat. Xenobiotica 8(12):761–768

I stopped the Curcumin but the pains and vomiting continued for more than a week. From the way I was feeling, I felt that death would be a better option… seriously! Not only this, but I had no energy whatsoever. Bottom line: Because of all the vomiting I became severely dehydrated and could barely stand without feeling I was going to pass out. I was so scared that I eventually called an ambulance and was rushed to A&E. My heart was racing at double its normal speed along with arrhythmia, and my blood pressure was almost zero. Research has shown curcumin may be beneficial for your kidneys. Specifically, curcumin may help in healing acute kidney injuries and increasing antioxidants. Certain individuals may take curcumin without any adverse effects for an extended term (e.g. months/years) until they notice some side effects. Initially they may not suspect that it’s the curcumin, but they may skip doses and realize that these effects subside when they don’t use it. In some cases, long-term side effects may occur among curcumin users, especially those taking high doses on a daily basis.The duration over which you’ve been taking curcumin may affect whether you’re likely to experience side effects. Short-term users may be less likely to experience side effects simply because they are taking low doses and/or haven’t taken curcumin long enough to elicit a significant physiologic response. In other cases, short-term users may report numerous and/or severe initial side effects, but as the body adapts to its effects, these initial side effects may subside.