Activon Medical Grade Manuka Honey 25g (Pack of 3)

Product Information

Zone of inhibition induced by the herbal gel formulation was greater than honey alone (35.1 mm vs 13.1 mm respectively). Using a dressing will help protect the wound and ensure the Activon Manuka Honey remains in the wound. What doesActivon Medical Grade Manuka Honey contain Clindamycin, gentamicin, and oxacillin Medihoney combinations induced antagonistic effects against S. aureus established biofilms when honey was used at sub-inhibitory concentrations but not at inhibitory concentrations.

Rifampicin and manuka honey considered to be most effective as demonstrated synergistic antimicrobial activity against all tested strains including planktonic bacteria and S. aureus biofilm formation. Versatile Healing Power: Whether it's a human's pressure ulcer or a pet's sore, this tube is your go-to solution. The various bioactivities of honey work together for a rapid healing — honey rapidly debrides wounds (ie. cleans the wound by releasing pus or dead tissue), kills bacteria, directly suppresses inflammation, and stimulates the growth of the various types of cells involved in the production of new tissue to repair the wound. It will de-bride and de-slough, eliminate odours and provides a moist wound healing environment. For each honey type there was > 90% decrease in the MIC when 3% (v/v) royal jelly was added; a 66.6% decrease when 2% (v/v) royal jelly was added and a 50% decrease in MIC when 1% (v/v) royal jelly was added.

PROs

Synergistic antimicrobial activity of Medihoney and rifampicin combination against MRSA and clinical isolates of S. aureus.

picture source: http://www.advancis.co.uk/products/activon-manuka-honey/activon-tube and http://www.advancis.co.uk/products/super-absorber-dressings/eclypse Clindamycin or oxacillin manuka honey combinations demonstrated synergistic antimicrobial activity against most strains (planktonic and biofilm formation) but not all.

Savlon Antiseptic Cream - 15g

Safety First: Please note that Activon Tube is not suitable for individuals allergic to bee venom. Some initial discomfort might occur but usually subsides. If persistent, cease use and consult a medical professional. Other therapeutic agents being considered for use in combination with honey for the treatment of wounds include honey and bacteriophage therapy, honey supplemented with antimicrobial peptides, honey combined with cyclodextrins or hydrogel, or honey and laser therapy. Novel approaches to wound healing have involved adding a combination of antimicrobial agents to nanofibrous scaffolds. For example, Sarhan and Azzazy (2017) 50 reported that honey (Egyptian clover) (30%) chitosan nanofibers loaded with bee venom (0.01%) and bacteriophages had superior antimicrobial activity in a broth culture assay against MDR P. aeruginosa in comparison to ionic silver containing Aquacel-Ag wound dressing. Furthermore, the novel honey bacteriophage dressing demonstrated better wound healing ability in mice when compared to Aquacel-Ag wound dressing. Oliveira et al (2017) 51 also reported synergistic antimicrobial effects against E. coli biofilms formed on 96 well plates at 12 and 24 hours using multi-floral Portuguese honey and an E. coli specific bacteriophage. This approach combines the antibiofilm effects of honey with the ability of bacteriophages to lyse bacteria. Scanning electron microscopy revealed that honey caused perturbations in the membrane of the E. coli whilst the bacteriophage caused complete lysis with only vesicle structures left behind. Synergistic antimicrobial activity against MRSA for manuka honey and tetracycline, imipenem and mupirocin combinations and additive activity against P. aeruginosa for manuka honey and tetracycline, rifampicin and colistin combinations. Discomfort can be experienced when honey is applied, depending on sensitivity of the wound it may be necessary to consider an appropriate level of analgesia. The initial discomfort usually subsides, however if it does continue, discontinue use and irrigate the wound with saline solution. How to Use Long-Lasting: Presented in a convenient 25g tube, Activon Tube remains effective for 90 days once opened.

The first thing that should be done is to remove the cause of the inflammation, which is to kill the infecting bacteria and remove any pus or dead tissue, that provide a medium for their growth. How does honey heal? L-Mesitran demonstrated antifungal activity against C. albicans (MIC 25%–50%), whereas 40% Mexican yucatan honey did not. Medical grade honey is manuka honey that has been was sterilized from all impurities and microorganisms (spores). Wear time will depend on the level of exudate but Eclypse can be left in place for up to seven days. Eclypse can be used under compression therapy.

EMLA Cream 5% - 5g

Low pH. Usually between 3.3 and 4.6, with some exception: chestnut honey (pH, between 5 and 6) and honeydew honey (pH between 4.5 and 6.5). The MIC of the combination of honey, cinnamaldehyde and carvacrol was lower than honey alone (0.49µg/mL vs 114.2 μg/mL respectively). The antibacterial activity of the triple combination was reportedly greater than imipenem. Kwakman et al (2011) 52 investigated the antimicrobial effects of supplementing Revamil honey with the antimicrobial peptides LL-37 and the synthetic peptide bacterial peptide 2 (BP2). They reported that the antimicrobial activity of LL-37 was inhibited in the presence of honey, but this was not the case for BP2. Using a liquid bactericidal assay, it was shown that Revamil honey supplemented with 75µM BP2 had more rapid antibacterial activity against MRSA and extended spectrum β lactamase (ESBL) E. coli and had a broader spectrum of antibacterial activity than Revamil alone. The authors considered supplementing the honey with hydrogen peroxide or MGO but were concerned that high levels of these components may not be biocompatible.

Gel composed of herbal extracts of Acacia catechu, Castanea sativa, Ephedra sinica and Momia combined with honey (25%), maple saps, Phoenix dactylifera (date), pomegranate extract and Azadirachta indica gum If the area of the wound is showing the classical signs of inflammation: redness, pus, swelling and pain.

Activon Manuka Honey Tube

There will be high levels of exudate, but this is perfectly normal. It will decrease over time, therefore your secondary dressing of choice may initially need to be super absorbent. For this, the producer of Activon recommends using Eclypse – Super Absorber Dressings. Honey and ginger combination induced higher mean zones of inhibition than honey or ginger alone or standard antibiotic discs (methicillin, penicillin, amoxicillin). If you need recurring bulk supply for a business, restaurant, or retail store, we can set you up with a business account. This provides benefits like discounted pricing, dedicated account management, and tailored delivery options. Twist off the cap and apply to the wound bed to a minimum depth of 5mm and cover with an appropriate secondary dressing. Activon Tube is a single patient use only product, once opened use within 90 days. Other researchers support the occurrence of enhanced effects of honey and antibiotics. Klein et al (2020) 31 used a broth culture assay to investigate the ability of subinhibitory concentrations of a range of medical grade honeys (Comvita ® Manuka Medihoney ®; Comvita ® Medihoney ® Antibacterial Wound Gel™; Revamil ® gel; and Surgihoney™RO ®) to enhance the activity of antibiotics (tetracycline, sulphatriad, streptomycin, penicillin G, chloramphenicol and ampicillin) against S. aureus and P. aeruginosa. In their study, bacteria were incubated aerobically overnight in broth cultures containing 10% honey. Samples from these cultures were then spread onto TSA plates and antibiotic discs (Mastring-S, Mast Group Ltd) were added to the agar and incubated at 37°C. The researchers found that the ability of the honeys to enhance the activity of the antibiotic depended on the type of honey, the antibiotic, and the bacterial species. Their key findings were that Surgihoney™RO ® and Comvita ® Medihoney ® Antibacterial Wound Gel™ increased the activity of tetracycline and ampicillin against S. aureus and increased the activity of tetracycline against P. aeruginosa.