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Linagliptin is a new oral antidiabetic agent. LNG isn’t available a specific analytical method in pharmacopeia. LNG has many articles that aim to assay LNG by HPLC, this method needs expensive solvents and specific equipments. So, this paper was described a new, simple analytical method depending in condensation reaction between LNG with PDAB as a chemical reagent for determination LNG in bulk and pharmaceutical dosage. The conditions of optimal conditions of this analytical research were studied and it was found that distilled water and methanol were the best solvents for both LNG and PDAB, 1mL of PDAB 5% as a derivative reagent with 2mL of HCl 37% as an acidic medium with heating to 70–75°C on a water bath for 35min to form the yellow Schiff base with a wavelength at 407nm and the stability of Schiff base formed for one hour. Validation of the proposed method was showed that this reaction has linearity 5–45μg/mL, according to the correlation coefficient R 2 = 0.9989 with percent recovery (99.46–100.8%) within an accepted criteria and RSD was less than 2%, so this proposed method has good accuracy and precision and high specificity. Furthermore, the molar ratio of this reaction was selected between LNG and PDAB it was (1:1) complex depending on two methods the Job of continuous variations and molar ratio. Preparation of Linagliptin Standard Solution (2 × 10 –3mol/l) by weighted 94.5mg of LNG in 100mL of distilled water.
Badugu, L. R. A validated RP-HPLC method for the determination of linagliptin. Am. J. Pharm. Tech. Res. 2(4), 463–470 (2012). apparatus and instruments for recording, transmitting, reproducing or processing sound, images or data; Preparation of ρDAB (2 × 10 –3mol/l) solution by dissolving 29.8mg in 100mL of methanol with good shaking, was freshly prepared. Linagliptin—PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Linagliptin#section=Structures, Accessed 19 Jan 2022.The researcher tested different volumes of HCI 37% (1–3mL), to select the appropriate acidic medium volume for LNG and PDAB reaction. The best results were obtained with 2mL of HCl 37% (Fig. 3c). Selection of temperature CHMP. Trajenta-Assessment Report-Committee for Medicinal Products for Human Use (CHMP) (Eur Med Agency, 2011). The effect of prolonged heating time on this reaction was controlled by monitoring the color development at different time intervals (10–60min) at 70–75°C. Maximum absorbance values were gained at 35min (Fig. 3b). Stability of the reaction product
Sri, K. V. V., Anusha, A. & Sudhakar, M. UV-spectrophotometry method for the estimation of linagliptin in bulk and pharmaceutical formulations. Asian J. Res. Chem. 9(1), 47 (2016). Safe & Reliable: This type c charger is designed with double insulation protection and passed UKCA/CE Safety certified tests, safe to use and protect your device against over-voltage, over-current, over-heating, short-circuiting issues and ensures a safer and more stable charging for your usb-c device. Durga Anumolu, P. et al. Quantification of linagliptin by chemical derivatization with appliance of chromogenic. J. Appl. Chem. Res. 11(2), 39–50 (2017).Gurrala, S., Anumolu, P. D., Menkana, S., Gandla, N. & Toddi, K. Spectrophotometric estimation of linagliptin using ion-pair complexation and oxidative coupling reactions—a green approach. Thai J. Pharm. Sci. 44(4), 245–250 (2020). Dalal, A., Tegeli, V. & Waghmode, R. Development and validation of a simple and rapid UV spectrophotometeric method for linagliptin in bulk and marketed dosage form. Der. Pharma Chem. 14(2), 23–26 (2022). Compact and Portable: Mini and lightweight design makes this 20W usb c power adapter a perfect travel companion, Handy for home, office, and on vacation. easy to take out or put inside your bag. Sample was prepared by mixing mannitol 20mg, maize starch 30mg, pregelatinized starch 30mg, copovidone 5mg and magnesium stearate 4mg 16. These excipients were analyzed by proposed method. The results were referred good recovery 101.157% and RSD = 0.8387%. These means no interference between excipients and determination of LNG in pharmaceutical dosage by this derivative method. Robustness
Fda, Cder, Beers, Donald. Analytical Procedures and Methods Validation for Drugs and Biologics Guidance for Industry (2015).Widely Compatibility: TEGELI PD 20W USB C Charger plug is compatible with iPhone 14/13/13 pro/13 pro max /iPhone 12 / 12 Pro / 12 Pro Max / 12 Mini / 11/11 Pro / 11 Pro Max / 11 Mini / 10/10 Max / iPhone 8 / iPhone 7 / iPhone 7 plus / iPhone 6s / iPhone 6, Samsung Galaxy S21 / Galaxy S21 + / Galaxy S21 ultra / Galaxy S20 / Galaxy S10 / Galaxy S9 / Galaxy S8 / Note / Tab / A series. The research method which is adopted for this paper was an experimental design that used an analytical approach to explore the research objectives. Instrumentation
Ntoi, L. L. A. & Von Eschwege, K. G. Spectrophotometry mole ratio and continuous variation experiments with dithizone. Afr. J. Chem. Educ. 7(2), 59–92 (2017). Linagliptin isn’t available as a specific method for analyzing in British pharmacopeia (BP) or the United States Pharmacopeia (USP). The Review of Research Literature has shown several articles for the determination of LNG in pharmaceutical forms, including the spectrophotometer in UV 3, 4, 5, also in VIS with chemical derivation using NQS (1,2-naphtho quinine 4-sulphonic acid sodium salt), vanillin 6 and picric acid 7 as a chromogenic reagents. Capillary Electrophoresis (CE) 8, and with high-performance liquid chromatography (HPLC) 9, 10, 11, 12, 13. Those methods are specificity and selectivity but they need more time, a lot of amount an expensive solvent and equipments. Aliquots volume of working solution LNG were moved into series of 10mL volumetric flasks to perform final concentrations of 5–45ppm. To each flask was added 1mL of ρDAB 5% (w/v) and 2mL of HCl 37%, then to the water bath at 70–75° for 35min after closed and shaking very well, after those flasks were cooled and diluted to 10mL by distilled water. The maximum absorption of the yellow color was 407nm upon the blank. The amount of linagliptin was calculated from the calibration curve. Baink, S., Kaisar, M. M. & Hossain, M. S. Development and validation of a simple and rapid UV spectrophotometer method for assay of linagliptin in bulk and marketed dosage form. Indian J. Nov. Drug. Deliv. 5(4), 221–224 (2013). Scientific, research, navigation, surveying, photographic, cinematographic, audiovisual, optical, weighing, measuring, signalling, detecting, testing, inspecting, life-saving and teaching apparatus and instruments;w/v): 1.25 g was dissolved in 25 mL of methanol with good shaking, and was freshly prepared. Analytical procedure Barapatre, S. R., Ganorkar, A. V. & Gupta, K. R. Quality by design-based HPLC assay method development and validation of linagliptin in tablet dosage form. Eur. J. Pharm. Med. Res. 4(02), 486–494 (2017). apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling the distribution or use of electricity; Freeman, M. K. Efficacy and safety of linagliptin (tradjenta) in adults with type-2 diabetes mellitus. J Clin Pharm Ther. 36(12), 807 (2011).
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