Joined in 2023 
82 
63 About this deal
Beyond personal perception, the impact of Iso E Super on others is truly remarkable. It lends an indefinable allure to the wearer, captivating those who encounter its aroma. Its effect is reminiscent of pheromones, drawing attention and fascination without a clear explanation. If the proposed SCCS Opinion is taken forward into legislation then OTNE will be labelled on cosmetic products in the EU, several years after publication of a new legislation.
Iso E Super is a molecule that hovers close to the skin to create an indefinable aura around the wearer. The International Fragrance Association (IFRA) has published safe use levels for Iso E Super in consumer products. [10] Klashka; etal. (2013). "Occurrences and potential risks of 16 fragrances in five German sewage treatment plants and their receiving waters". Environ. Sci. Pollut. Res. 20 (4): 2456–71. doi: 10.1007/s11356-012-1120-9. PMID 22945655. S2CID 31312476.OTNE is classified as H410 Very toxic to aquatic life with long-lasting effects ( EU-CLP) or R51/53 Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment (EU DSD). [7] The fragrance Eternity by Calvin Klein (1988) contained 11.7% Iso E Super in the fragrance portion of the formula. Belsito; etal. (2013). "A toxicological and dermatological assessment of alkyl cyclic ketones when used as fragrance ingredients. RIFM Expert Panel". Food and Chemical Toxicology. 62: S1-44. doi: 10.1016/j.fct.2013.09.033. PMID 24246175.
OTNE has been recommended for inclusion in an update for the EU Fragrance Allergens labelling for cosmetic products based on a small number of positive reactions in dermatological clinics of around 0.2% to 1.7% of patients tested in three studies [18] The measured Bio Concentration Factor (BCF) is 391L/kg, which is well below the EU limit of 2000 and US limit of 1000 for Bioaccumulation (B) classification. The LogKow for OTNE has been measured to be 5.65. [7] No data were available regarding chemical disposition, metabolism, or toxicokinetics; acute, short-term, subchronic, or chronic toxicity; synergistic or antagonistic activity; reproductive or teratological effects; carcinogenicity; genotoxicity; or immunotoxicity. [5] Given the sensitization classification of OTNE, and its use in fragrances, the International Fragrance Association (IFRA) has published safe use levels for OTNE in consumer products, which have been in effect since August 2009. [14] Environmental data [ edit ]Carrying out the initial Diels–Alder reaction using a Lewis acid catalyst such as aluminum chloride appears to ensure that the acetyl group is at position 2 of the resulting cyclohexene adduct, which distinguished Iso E Super from other (previously patented) fragrances based on tetramethylacetyloctaline. The second cyclization reaction yields a mixture of diastereomers with the general structure depicted above, the predominant ones being (2 R,3 R) and (2S,3S). [1] Chemical Summary [ edit ] OTNE is therefore not classified as a PBT or vPvB substance [7] for the EU or any other global criteria. The biodegradation of OTNE in fresh water (T1/2) is at most 40 days, and at most 120 days in sediment (OECD 314 test), though the biodegradation within the 28day window was around 11% (OECD 301-C). Given the outcome of the OECD 314 test OTNE does not meet the criteria for “Persistent” (P) or “very Persistent” (vP).
Scientific Committee on Consumer Safety (2011). "Annex I: Clinical evidence regarding sensitisation to individual fragrance chemicals and to natural extracts" (PDF). SCCS Opinion on fragrance allergens in cosmetics. European Union. p.63. SCCS/1459/11. Discover the captivating nature of Iso E Super, an aroma-chemical that transcends traditional fragrances. Experience the allure of its sweet cedarwood-like scent and embrace the intrigue it brings to both the wearer and those around them. Bester, K. (Nov 2008). "Surface water concentrations of the fragrance compound OTNE in Germany--a comparison between data from measurements and models". Chemosphere. 73 (8): 1366–72. Bibcode: 2008Chmsp..73.1366B. doi: 10.1016/j.chemosphere.2008.06.057. PMID 18715610. Iso E Super is produced commercially by Diels–Alder reaction of myrcene with 3-methyl-3-penten-2-one in the presence of aluminium chloride to give a monocyclic intermediate that is cyclized in the presence of 85% phosphoric acid. [6] Synthesis
International delivery
a b US 3929677,Hall, John B.&Sanders, James Milton,"Perfume composition and perfume articles containing one isomer of an octahydrotetramethyl acetonaphthone",issued 1975
The distinction of Iso E Super lies in its design as an aroma-chemical rather than a traditional fragrance. Ordinary fragrances are crafted to project themselves over a wide radius, while Iso E Super is specifically formulated to cling to the skin, effortlessly oscillating between moments of opulence and simplicity. This duality allows it to be at times distinctly noticeable and at other times undetectable, creating an intriguing and ever-changing olfactory experience. The wearer may perceive a subtle, velvety, and woody note that momentarily fades away, only to resurface after some time, enhancing the fragrance's allure and complexity. Iso E Super has a marked intermittence. To the wearer, it seems to vanish and then re-appear. This is due to the way it bonds with receptors in the olfactory system, only slowly releasing to make way for a fresh charge of the molecule on the receptors.
My Account
Stagnant water, charcoal, semen... 10 smells that changed the perfume industry". The Telegraph . Retrieved 2017-06-21.
Great Deal 
New Comment