Kuby Immunology: 7th Edition: International Edition

Product Information

The effects of bacterial lipopolysaccharide on macrophages are mediated by CD14 binding to Toll-like receptor 4 Rearrangement at the immunoglobulin light-chain locus leads to cell-surface expression of the B-cell receptor Toll-like receptors recognize microbial molecules, signal cell to secrete immunostimulatory cytokines. where she studied multiple sclerosis. She then spent 3 years exploring transplant immunology as a postdoctoral fellow

Antibodies against cell-surface molecules have been used to remove specific lymphocyte subsets or to inhibit cell function Newly synthesized MHC class I molecules are retained in the endoplasmic reticulum until they bind peptide Binding of the T-cell receptor complex directs the release of effector molecules and focuses them on the target cellX-linked lymphoproliferative syndrome is associated with fatal infection by Epstein-Barr virus and with the development of lymphomas

Some pathogens resist destruction by host defense mechanisms or exploit them for their own purposes Malignant lymphocyte tumors frequently carry chromosomal translocations that join immunoglobulin loci to genes regulating cell growthJudy Owen holds B.A. and M.A. (Hons) degrees in biochemistry from Cambridge University. She pursued her Ph.D. at T cells specific for self antigens can cause direct tissue injury and have a role in sustained autoantibody responses An important question is whether vaccination can be used therapeutically to control existing chronic infections

Innocuous antigens can cause type II hypersensitivity reactions in susceptible individuals by binding to the surfaces of circulating blood cells Complement control proteins regulate all three pathways of complement activation and protect the host from its destructive effects Bacterial peptides, mediators of inflammatory responses, and chemokines signal through members of the seven-transmembrane-domain, trimeric G protein-coupled receptor family Stages in B-cell development are distinguished by the expression of immunoglobulin chains and particular cell-surface proteins

Similar Items

The humoral immune response is initiated when B cells that bind antigen are signaled by helper T cells or by certain microbial antigens alone Understanding adaptive immune responses is important for the control of allergies, autoimmune disease, and organ graft rejection New In-Class Group Work activity: We've created a big picture concept map, for in-class group work, that is included within the Active Lecture Slides. Peptides are stably bound to MHC molecules, and also serve to stabilize the MHC molecule on the cell surface Repeated immunizations lead to increasing affinity of antibody owing to somatic hypermutation and selection by antigen in germinal centers

Effector T-cell interactions with target cells are initiated by antigennonspecific cell-adhesion molecules Complement is a system of plasma proteins that interacts with pathogens to mark them for destruction by phagocytes Effector T-cell interactions with target cells are initiated by antigen-nonspecific cell-adhesion molecules Both specific ligand and co-stimulatory signals provided by an antigen-presenting cell are required for the clonal expansion of naive T cellsThe nonspecific responses of innate immunity are necessary for an adaptive immune response to be initiated in Biochemistry for 12 years. Sharon is now a professor of biology at Pomona College in Claremont, California, where Many genes that operate in fruit fly immunity also operate in humans and plants and appear to be universal components of host defense