HealthAid Karela Extract 1250mg 60 Tablets

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Kumar KPS, Bhowmik D. Traditional medicinal uses and therapeutic benefits of Momordica charantia Linn. Int J Pharm Sci Rev Res. 2010;4(3):23–8. Available at: https://globalresearchonline.net/journalcontents/volume4issue3/Article%20004.pdf Lee-Huang S, Huang PL, Huang PL, et al. Inhibition of the integrase of human immunodeficiency virus (HIV) type 1 by anti-HIV plant proteins MAP30 and GAP31. Proc Natl Acad Sci U S A 1995;92:8818-22. View abstract. Takemoto, D. J., Jilka, C., and Kresie, R. Purification and characterization of a cytostatic factor from the bitter melon Momordica charantia. Prep.Biochem 1982;12(4):355-375. View abstract. It’s also high in vitamin A, a fat-soluble vitamin that promotes skin health and proper vision ( 3).

Furthermore, karela is rich in zinc, which is essential for maintaining a healthy immune system. Zinc helps activate immune cells and is required to produce antibodies that fight infections. 4. Promotes Weight Loss Schreiber CA, Wan L, Sun Y, et al. The antiviral agents, MAP30 and GAP31, are not toxic to human spermatozoa and may be useful in preventing the sexual transmission of human immunodeficiency virus type 1. Fertil Steril 1999;72:686-90. View abstract. Karela has been used for centuries in traditional medicine to help manage diabetes. It is because it contains a compound called charantin, which has been shown to have blood sugar-lowering properties. In addition, karela is rich in a type of insulin-like compound called polypeptide-p, which helps in regulating the blood sugar levels in people with type 2 diabetes. Karela Juice: Take 10-15 ml of karela juice and add the same amount of water. Mix and drink it on an empty stomach once a day to reap its benefits.Ali L, Khan AK, Mamun MI, et al. Studies on hypoglycemic effects of fruit pulp, seed, and whole plant of Momordica charantia on normal and diabetic model rats. Planta Med 1993;59:408-12. View abstract. A series of abnormalities linked with diabetes and delayed wound healing are lowered immune response, reduced formation of new blood vessels, deficiency of growth factors, and reduced production of collagen. When karela fruit ointment was applied to the rat (diabetic rat), it showed a potential to improve wound closure and may help enhance a gene that helps in cell growth. Therefore, it might be beneficial for the healing of the wound. 1 However, more research is required to prove such effects on humans.

Another study in 40 people with diabetes found that taking 2,000 mg per day of bitter melon for 4 weeks led to a modest reduction in blood sugar levels. Somasagara RR, Deep G, Shrotriya S, Patel M, Agarwal C, Agarwal R. Bitter melon juice targets molecular mechanisms underlying gemcitabine resistance in pancreatic cancer cells. Int J Oncol. 2015;46(4):1849-57. View abstract. Anila L, Vijayalakshmi NR. Beneficial effects of flavonoids from Sesamum indicum, Emblica officinalis and Momordica charantia. Phytother Res 2000;14:592-5. View abstract. In January 2011, the results of a four-week clinical trial were published in the Journal of Ethnopharmacology , which showed that a 2,000 mg daily dose of bitter melon significantly reduced blood glucose levels among patients with type 2 diabetes, although the hypoglycemic effect was less than a 1,000 mg/day dose of metformin . [68] Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, et al. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res 1993;7:285-9.However, research in humans is limited, and larger, more high-quality studies are needed to understand how bitter melon may impact blood sugar levels in the general population. Summary Lee-Huang S, Huang PL, Chen HC, et al. Anti-HIV and anti-tumor activities of recombinant MAP30 from bitter melon. Gene 1995;161:151-6. View abstract. It is also known that bitter melon contains a lectin that reduces blood glucose concentrations by acting on peripheral tissues and suppressing appetite – similar to the effects of insulin in the brain Leatherdale B, Panesar RK, Singh G, et al. Improvement in glucose tolerance due to Momordica charantia. Br Med J (Clin Res Ed) 1981;282:1823-4. View abstract. Karela has been used in our country since ages to help in regulating blood sugar levels in diabetics. It contains compounds “charantin” and “vicine”, which have glucose lowering properties. It also contains polypeptide-p, which has insulin-like properties i.e. it increases glucose absorption by cells of the body and reduces blood glucose levels. These substances, either work individually or together and help reducing blood sugar levels. Karela also has lectin, which acts on cells and tissues of our body and increases their sugar intake and it also suppresses appetite by acting on the brain.

In fact, it can be pan-fried, steamed, baked, or even hollowed out and stuffed with your choice of fillings.Keep in mind that these studies were performed using concentrated amounts of bitter melon extract on individual cells in a laboratory. The juice of fresh leaves of karela is found to be beneficial for piles. Have 3 teaspoonfuls of the leaf juice mixed with a glass of chaach (buttermilk) every morning for about a month to relieve piles. Or else, you can apply a paste of the roots of karela plant over the piles for healing. Cortez-Navarrete M, Méndez-Del Villar M, Martínez-Abundis E, et al. Effect of Momordica charantia administration on anthropometric measures and metabolic profile in patients with obesity: a pilot clinical trial. J Med Food 2022. View abstract. Kwak JJ, Yook JS, Ha MS. Potential biomarkers of peripheral and central fatigue in high-intensity trained athletes at high-temperature: a pilot study with Momordica charantia (bitter melon). J Immunol Res. 2020;2020:4768390. View abstract.

Vikrant V, Grover JK, Tandon N, et al. Treatment with extracts of Momordica charantia and Eugenia jambolana prevents hyperglycemia and hyperinsulinemia in fructose fed rats. J Ethnopharmacol 2001;76:139-43. View abstract. Shekelle, P. G., Hardy, M., Morton, S. C., Coulter, I., Venuturupalli, S., Favreau, J., and Hilton, L. K. Are Ayurvedic herbs for diabetes effective? J Fam.Pract. 2005;54(10):876-886. View abstract. Rebultan, S. P. Bitter melon therapy: an experimental treatment of HIV infection. AIDS Asia 1995;2(4):6-7. View abstract. Akhtar, M. S. Trial of Momordica charantia Linn (Karela) powder in patients with maturity-onset diabetes. J Pak.Med Assoc 1982;32(4):106-107. View abstract.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency: Karela seeds might cause severe anaemia in people with G6PD deficiency. Therefore, it is better to avoid using karela if you have G6PD deficiency. 7 Furthermore, karela contains compounds that have been shown to have properties that can help in reducing inflammation in the skin. It makes karela an excellent food for people who suffer from skin conditions such as acne, eczema, and psoriasis.