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Chatree S, Thongmaen N, Tantivejkul K, Sitticharoon C, Vucenik I Role of Inositols and Inositol Phosphates in Energy Metabolism. Molecules. (2020-Nov-01) Cheang KI, Baillargeon JP, Essah PA, et al. Insulin-stimulated release of D-chiro-inositol-containing inositol phosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndrome. Metabolism. 2008 Oct; 57(10): 1390-7. The pooled analysis of eight RCTs showed a higher reduction in BMI in the inositol group compared to placebo (MD = -0.45 kg/m 2, CI: -0.89; -0.02, Figure S 2a). Particularly, myoinositol seems to have a beneficial effect on weight loss MD = -0.71 kg/m 2 (CI: -1.00; -0.43 kg/m 2, Figure S 2b.).
Therefore, inositol has been explored for its potential to improve the body’s sensitivity to insulin — thus, reducing insulin resistance. The clinical applications of myo-inositol are already wide ranging and it’s likely, as research in the area gathers momentum, more may be added. For women with PCOS though, research shows that myo-inositol is a useful consideration as part of their treatment protocol.Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41–7.
Motuhifonua SK, Lin L, Alsweiler J, Crawford TJ, Crowther CA Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes. Cochrane Database Syst Rev. (2023-Feb-15) Folic Acid is imperative for the healthy development of a baby’s brain and spine*. We’ve included the recommended 400mg Folate (Department of Health) in the form of 5-Methyltetrahydrofolate Calcium, which is easier and faster for the body to absorb than folic acid.Supports normal hormonal activity: Our all-in-one Myo-inositol Preconception supplement has been formulated to support normal hormonal activity, which is necessary for a healthy menstrual cycle, giving you more control over your most fertile time of the month. In the case of DHEAS and androstenedione, no significant difference was found. Results are mostly consistent with those of Zeng et al., but other inositol stereoisomers were also investigated in the present study [ 54] They found no statistical difference between myoinositol and the placebo group regarding total testosterone levels. However, on the basis of two articles, they found a decrease in free testosterone. In comparison with Pundir et al., one more RCT was included in the present analysis [ 31], and no difference was found in DHEAS levels after inositol treatment compared to placebo [ 19, 31]. On the other hand, Kutenai et al. reported that myoinositol reduced total testosterone and DHEA level more effectively than metformin [ 55]. These results might be the consequence of the more effective aromatase activity. For higher daily intake of Myo-inositol, you can supplement Preconception with two tablets of Myoplus per day.This results in a total daily dose of 4000mg of Myo-inositol and 600ug of Folate, safe for women trying to become pregnant. It's not recommended to combine the Preconception with Balance, Metabolism, or Hair, Skin & Nails. How to use it IntHout J, Ioannidis JP, Borm GF. The Hartung-Knapp-Sidik-Jonkman method for random effects meta-analysis is straightforward and considerably outperforms the standard DerSimonian-Laird method. BMC Med Res Methodol. 2014;14:25. Weight - Gerli S, Mignosa M, Di Renzo GC Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial Eur Rev Med Pharmacol Sci. (2003 Nov-Dec)
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