ICE IR 77mm 77 Slim Filter Infrared Infra-Red 850HB 850nm 850 Optical Glass

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Across our global natural gas business, the expansive breadth of our benchmarks was evident. As Europe looks for solutions to fill the void created by Russian natural gas no longer flowing to the continent, our North American natural gas markets benefitted from the new demand center created last year within the EU for U.S. LNG. We use non-GAAP measures internally to evaluate our performance and in making financial and operational decisions. When viewed in conjunction with our GAAP results and the accompanying reconciliation, we believe that our presentation of these measures provides investors with greater transparency and a greater understanding of factors affecting our financial condition and results of operations than GAAP measures alone. In addition, we believe the presentation of these measures is useful to investors for period-to-period comparison of results because the items described below as adjustments to GAAP are not reflective of our core business performance. These financial measures are not in accordance with, or an alternative to, GAAP financial measures and may be different from non-GAAP measures used by other companies. We use these adjusted results because we believe they more clearly highlight trends in our business that may not otherwise be apparent when relying solely on GAAP financial measures, since these measures eliminate from our results specific financial items that have less bearing on our core operating performance. We strongly recommend that investors review the GAAP financial measures and additional non-GAAP information included in our Annual Report on Form 10-K, including our consolidated financial statements and the notes thereto. Both ice and heat are pointless or worse when unwanted: icing when you’re already shivering, or heating when you’re already sweating. The brain may interpret an excess of either one as a threat, but icing is more threatening — and when brains think there’s a threat, they may also amp up the pain. 4 Ice seems to be feel more threatening to most people. Zhao, Y., Chen, X. & Li, J. TGMin: a global-minimum structure search program based on a constrained basin-hopping algorithm. Nano Res. 10, 3407–3420 (2017). C omputational Chemistry Comparison and Benchmark DataBase (Release 20), https://cccbdb.nist.gov/vibscale.asp (NIST Standard Reference Database 101, August 2019).

Net revenues in constant currency are calculated holding both the pound sterling and euro at the average exchange rate from 4Q20 1.3207 and 1.1920 respectively.Who hasn’t experienced a headache of some degree? Some are lighter, easily treated with OTC pain relievers while others require some extra steps for relief. Ice can help soothe throbbing pain in your head. “Cold masks or wraps over the forehead, eyes and temples help the throbbing pain of a migraine,” says neurologist Jennifer Kriegler, MD. The five isomers I– V all have interesting cubic structures. The fact that the five cubic isomers I– V lie within 3 kcal/mol indicates that they can possibly coexist at the finite temperature of experimental condition. The interconversion barrier among them is larger than 4 kcal/mol at the MP2/AVDZ level (Supplementary Fig. 4). For instance, the interconversion between the two enantiomeric isomers III and IV need go through four transition states and three intermediates, with the largest barrier of about 5 kcal/mol. Such interconversion barrier might be sufficiently large so that the ultra-high-pressure supersonic expansion cooling is capable of kinetically quenching the non-equilibrium octamer system prior to its rearrangement to the global-minimum-energy structure 22. Quenching in our experiment produces a non-equilibrium distribution, which benefits to the observation of all five cubic isomers. To evaluate the temperature effect on the distribution of the isomers, Gibbs free energies Δ G of isomers I– V were calculated for the temperature from 0 to 300 K (Supplementary Fig. 5). Clearly, the free energy difference Δ G II–I, Δ G III–I, Δ G IV–I, and Δ G V–I does not alter significantly below room temperature, indicating that the population of the five isomers changes little at low temperature. Analysis of the electronic structure

In a similar vein, Gasoil, our global benchmark for refined products, last year faced a market that was initially self-sanctioning in the aftermath of the invasion and later became subject to EU sanctions on Russian oil. In response, ICE created a novel solution to change Gasoil’s contract specification to exclude Russian oil. As market structures have evolved, we have worked with our customers to provide the most efficient and lowest-latency connectivity to the venues that matter most to them through our ICE Global Network and Consolidated Feeds services. Following Euronext’s migration to Bergamo, Italy, and in response to demand from customers for low-latency connectivity to markets throughout the region, we expanded our wireless network to offer market data and private bandwidth services between Bergamo, Frankfurt, and London. Ice feels more “threatening” to most people, and pain is fundamentally the sensation of danger. If the brain thinks there’s trouble, pain ramps up. Unwanted cooling can increase the brain’s concern, and thus pain. See Pain is Weird.

What about injured muscle? Muscle strains?

Diversity: We are focused on increasing and supporting diversity through three pillars: our employee population, our Board of Directors, and our community of listed companies. In 2022, we took the additional step of setting specific key performance indicators for certain segments that we believe will help increase diversity throughout our organization. Our efforts to add diverse members to our own Board have resulted in an outstanding slate of company directors that is comprised of 60% women and 30% who self-identify as people of color. We have seen remarkable success with the NYSE Board Advisory Council, which develops and provides access to a diverse pool of CEO-vetted, board-ready candidates for companies seeking directors. Since its founding in 2019, more than 30 candidates identified by the council have joined boards, and our pool of qualified candidates has grown to over 500. There is substantial innovation underway in our environmental portfolio. Among the offerings we are excited about is hosting carbon credit auctions, which will allow companies to buy credits directly from project developers, connecting new customers to ICE and a range of forward-thinking carbon credit projects around the world. Pugliano, N. & Saykally, R. J. Measurement of quantum tunneling between chiral isomers of the cyclic water trimer. Science 257, 1937–1940 (1992).