A.Vogel Passiflora Complex drops - with Passion Flower Extract - 50ml

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Severe nervous system reaction with very stiff muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, and feeling like you might pass out; or

Paoletti A, Gallo E, Benemei S, et al. Interactions between Natural Health Products and Oral Anticoagulants: Spontaneous Reports in the Italian Surveillance System of Natural Health Products. Evid Based Complement Alternat Med. 2011;2011:612150. doi:10.1155/2011/612150

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The reasons for this gap are the complexity of a formulation based on natural products, which generally includes a high number of substances in its composition that can suffer qualitative and quantitative variation of these constituents due to many factors, such as plant harvest and climatic factors [ 80, 81]. Currently, it is possible to apply standardized methods for the preparation of herbal medicines with the chemical composition controlled. However, the identification of the active substance is usually difficult, and this fact can compromise the knowledge of the ADMET properties in the body [ 80, 82]. The study concluded that “oral premedication with Passiflora incarnata 500 mg reduces preoperative anxiety without inducing sedation or changing psychomotor function.” 13 Serious heart symptoms include fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness;

Dhawan, K., Kumar, S., and Sharma, A. Comparative biological activity study on Passiflora incarnata and P. edulis. Fitoterapia 2001;72(6):698-702. View abstract. With a name like passion flower, it can only be something kind, gentle and calming from nature. While that doesn’t hold true for all sweet names, it does hold true for the passion flower, a wildflower of striking beauty that produces a fleshy fruit, called passion fruit. Passionflower is bursting with sleep-promoting flavonoids. Apigenin seems to have a special affinity for the central benzodiazepine receptor and through this relationship may have ties to gamma-aminobutyric acid (GABA) receptors. 2 3 Another bioflavonoid by the name of chrysin is found in abundant supply in passionflowers. Similar to apignenin, chrysin has demonstrated anxiolytic, muscle relaxing, and sedative effects. 4 5Traditional doses for use as a mild sedative have included 0.5 to 2 g of P. incarnata aerial plant parts taken 3 to 4 times daily; 2.5 g of aerial parts as an infusion 3 to 4 times daily; or 1 to 4 mL of a tincture (1:8) 3 to 4 times daily. WHO 2007

Nassiri-Asl M, Shariati-Rad S, Zamansoltani F Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors. BMC Complement Altern Med. (2007-Aug-08) Mansoor K, Qadan F, Hinum A, et al. An open prospective pilot study of a herbal combination "Relief" as a supportive dietetic measure during alcohol withdrawal. Neuro Endocrinol Lett. 2018 Mar 1;39(1):1-8. View abstract. Passion flower is a plant in which the parts of the plant above the ground are used, in different forms, to provide natural healing purposes and food flavoring. You may have heard of passion flower tea or passion flower extract — it’s also found as infusions, teas, liquid extracts and tinctures.The alternative to deal with these peculiarities related to herbal medicines is the determination of ADMET properties of pure constituents of the formulation, through in vitro tests, for example, Caco-2 cells, human liver microsomes, and cultured human hepatocytes [ 80]. In this context, the ADMET properties of the flavonoids iso-orientin, isovitexin, luteolin, apigenin, and kaempferol present in P. incarnata have been described in the literature [ 80, 83, 84]. Distribution of preparations containing Passiflora incarnata registered in Europe Union, according to the European Medicines Agency [ 21]. 3. Conclusions

Movafegh A, Alizadeh R, Hajimohamadi F, Esfehani F, Nejatfar M Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: a double-blind, placebo-controlled study. Anesth Analg. (2008-Jun) He X, Luan F, Yang Y, Wang Z, Zhao Z, Fang J, Wang M, Zuo M, Li Y : An Insight Into Current Researches on Phytochemistry and Pharmacology. Front Pharmacol. (2020) Contraindicated during pregnancy. Use should generally be avoided in patients with cardiac arrhythmias and abnormalities. Pregnancy/Lactation Passion flower contains bioactive compounds and its medicinal benefits are believed to be from flavonoids such as apigenin. Animal studies indicate that passion flower extracts may have sedative, anxiety-relieving (anxiolytic), analgesic, and antispasmodic effects. Passion flower is thought to work by enhancing the levels and activity of gamma-aminobutyric acid (GABA), the primary inhibitory chemical messenger (neurotransmitter) in the brain.Allow it to steep for about 10–12 minutes. Remove from the stove, strain if needed and pour yourself a cup. Then add some local, organic honey if desired. Try this at any time when you may feel anxious or at night before bed. Risks and Side Effects Caution is warranted with concomitant consumption of CNS-active medicines and coadministration of drugs that prolong the QT interval. Adverse Reactions Analyses were conducted of the phytonutrient and antioxidant contents of the wild passion fruit species, specifically P. tenuifila and P. setacea. The researchers paid most attention to the seeds and the explants from seedlings, as well as the adult version. The high level of phenolic compounds showed the powerful antioxidant activity of the extract of the passion flower plant. Children: Passion flower is possibly safe for most children when taken by mouth for short periods of time. A specific passion flower product (Pasipay by Iran Darouk Pharmaceutical Company) has been used safely in children aged 6-13 years for up to 8 weeks.