Bio-Kult Advanced Multi-Strain Formulation Probiotic for Digestive System, 60 Count {Pack of 1}

Product Information

Fiecare capsulă conține: 2 miliarde de bacterii vii (2 x 10 9 UFC), viabile pe toată perioada de valabilitate, echivalent cu mai mult de 10 miliarde per gram (>1 x 10 9 UFC). Male and female patients aged 18 to 55years with moderate to severe IBS-D diagnosed according to Rome III criteria [recurrent abdominal pain or discomfort (an uncomfortable sensation not described as pain) at least three days a month in the past three months, associated with two or more of the following: improvement with defecation; onset associated with a change in frequency of stool; and onset associated with a change in form (appearance) of stool. The criteria should be fulfilled for the past three months with symptom onset at least six months before diagnosis]. Patients classified as IBS-D (diarrhea predominant) had >25% loose/wet motions (Bristol stool scale 6–7) and<25% firm/hard motions (Bristol stool scale 1–2). The severity of IBS was determined by the IBS Severity Scoring System (IBS-SSS) as described below.

Bacteria in supplements and fermented foods are generally transient in nature,” says Burton. “Some of the ingested bacteria may persist in the gut lining in the short term, but the majority exert a positive effect as they move through the gut, before being excreted via the stool. These bacteria are carefully freeze-dried to not only preserve them right to the end of the best-before date but also so they can pass undamaged through the stomach. Once in the gut, they are then free to grow and thrive. Each capsule contains: 2 billion microorganisms per capsule (2 x 109 CFU/capsule), equivalent to 10 billion microorganisms per gram (>1 x 1010 CFU/gram).

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Ingredients:Bulking agent: microcrystalline cellulose, live bacteria° ( milk, soya), vegetable capsule (hydroxypropyl methylcellulose). A recently published systematic review of probiotics undertaken by the British Dietetic Association (BDA) found that of 35 probiotic RCTs analysed, almost three-quarters were potentially pilot studies with a sample size too small (<50 patients/group) to develop any probiotic-specific clinical recommendations [ 41]. The sample size ( N=360) of the current study was based on robust statistical analyses to achieve adequate power and represents one of the largest probiotic IBS clinical trials to date. Moreover, the research recommendations from the BDA review called for high-quality RCTs of probiotics to consider IBS sub-type and to use validated symptom and QoL assessments [ 41]. In this regard our study only included patients with IBS-D, and assessments were performed using validated IBS-SSS and IBS-QoL instruments. Express Delivery (Please be aware when you select Courier Next Day for northern parts of Scotland, DPD may take 2 days to deliver)

For a daily probiotic supplement that won’t cost the earth, we love Holland & Barrett’s budget-friendly offering. The tablets are strawberry-flavoured and chewable, making them ideal for those with difficulty swallowing capsules; the delicious taste means you’re less likely to forget to take them, too.

Clinical research – The gold standard of evidence for efficacy of a product is clinical trials conducted in humans, showing significant positive outcomes. “Following the evidence of clinical trials when choosing a product is one of the best ways to ensure that you’re obtaining effective ingredients,” says Burton. “This information isn’t always prominently displayed, however, and the reason for this originates from the regulatory restrictions in health claims. As such, get in touch with manufacturers or health practitioners if you’d like to know more about a particular product in relation to its scientific evidence.” Strength – There are many different live bacteria supplements on the market at a wide range of strengths or CFUs (colony forming units), from 100 million to 900 billion CFUs per day. “Currently, there’s limited evidence to confirm a ‘dose-response relationship’, therefore firm conclusions can’t yet be made as to which CFU is ideal,” says Burton. “High strength isn’t always better –a 2016 systematic review by the British Dietetic Association suggested that the majority of IBS trials demonstrating clinical efficacy use CFU counts below 10 billion a day. So look for high-quality live bacteria supplements and the product as a whole, with evidence of viability [and] clinical efficacy, choosing strength and strain according to your needs.” For Travellers:1 week before travel follow guidelines for general use. During travel take 4 capsules daily. Continue to take for at least 1 week following the end of travel.