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KEY FEATURES•• Zinc Carnosine helps relieve symptoms of mild gastritis including gastrointestinal pain, nausea, abdominal distention and relieves symptoms of heartburn.
I will often experience bloating, reflux, gas, stomach cramps, and other issues after eating certain foods, but immediately after I started taking these capsules I have experienced no problems at all- even after eating trigger foods. " * Maes, A.; Huygh, I.; Weltens, C.; Vandevelde, G.; Delaere, P.; Evers, G.; Van den Bogaert, W. De Gustibus: Time scale of loss and recovery of tastes caused by radiotherapy. Radiother. Oncol. 2002, 63, 195–201. [ Google Scholar] [ CrossRef] The stand-alone ingredients in Doctor’s Best PepZin GI have known to be safe in limited amounts of dietary supplementation. Doctor’s Best PepZin GI does not contain any ingredients that have been known to pose any risks for health safety. Foods To Eat with Doctor’s Best PepZin GI? Consult your health practitioner before changing your prescribed drug therapy. Where is PepZinGI™ sold?Posthauer, M.E.; Banks, M.; Dorner, B.; Schols, J.M. The role of nutrition for pressure ulcer management: National pressure ulcer advisory panel, European pressure ulcer advisory panel, and pan pacific pressure injury alliance white paper. Adv. Ski. Wound Care 2015, 28, 175–188. [ Google Scholar] [ CrossRef][ Green Version] Doctor’s Best PepZin GI is said to be an effective supplement that can help with symptoms of gas, gluten intolerance, IBS, lactose intolerance, bloating, diarrhea and constipation. It alleges to improve symptoms that deal with the improper digestion of food and all the symptoms listed above. As one would find it hard to believe the effects of this supplement, their ingredient list has shown to have some sort of effect for digestive issues. Does Doctor’s Best PepZin GI Work? Over time, the delicate gut lining can become weak and more permeable than normal (due to things like gluten, periodic stress, too much exercise, unhealthy balance of gut bacteria, not eating as well as you should, pesticides and more, which can show up in the form of a variety of stomach discomforts, such as occasional: FODMAP-containing foods. (A category that includes many foods typically considered “healthy,” such as many vegetables and fruits.)
In an ethanol-induced gastro-injury rat model, ZnC treatment decreased the ulcer index of the rat stomach and showed a significant ulcer-healing effect similar to the gastric mucoprotective agent rebamipide [ 31]. Similarly, a significant ulcer healing effect was reported with ZnC supplementation compared with the placebo treatment group in an aspirin-induced gastroduodenal injury animal model [ 32, 33]. In addition, a study using an acetic acid-induced rat model reported that the ZnC treatment group showed a significant antiulcer effect and healing action compared to the control [ 34]. These results are most likely a result of the anti-inflammatory and antioxidant functions of ZnC [ 35]. This function of ZnC helps to explain the many other benefits it can exert throughout the GI tract. What’s more, glutamine is essential for supporting gut barrier integrity. Physical, mental, emotional, and environmental stress increase the body’s use of this key gut-nourishing nutrient. A meta-analysis (the gold standard of scientific evidence) found that glutamine reduced markers of increased intestinal permeability. And a research review stated that “glutamine holds great promise” in protecting the gut and for enhancing gut barrier health and function. 5,6 If you struggle with occasional digestive distress, skin issues, joint problems, mood issues, brain fog, fatigue, unhealthy cravings, or sleep problems, there’s a chance that the underlying issue may be unhealthy intestinal permeability (aka leaky gut). When the gut lining becomes weak, it allows foreign invaders to leak into your body. This can cause unwanted inflammation and a dysfunctional immune system. And that’s when things can go awry.Ko, J.K.; Leung, C.C. Ginger extract and polaprezinc exert gastroprotective actions by anti-oxidant and growth factor modulating effects in rats. J. Gastroenterol. Hepatol. 2010, 25, 1861–1869. [ Google Scholar] [ CrossRef] [ PubMed] PepZin® GI is a patented complex of zinc and l-carnosine that has been used for over 25 years for its gastro-supportive properties, which have been demonstrated in over 20 published studies. This special chelated form of zinc is released slowly in the stomach, allowing it to provide nutritional support for the health of the GI tract over a long period of time. Studies have shown that PepZin® GI provides support for occasional GI discomfort, a healthy gut lining, and a healthy GI environment, including a healthy balance of gut bacteria. PepZin® GI also the gut's immune funciton and a healthy expression of cytokines , which are both important for a healthy, balanced immune response. PepZin® GI also helps maintain the integrity of the stomach lining and a proper gastric immune response. Footnote † Lactobacillus rhamnosus maintains beneficial gut flora during antibiotic use and restores beneficial flora after antibiotic use. Follow an elimination-style diet to identify food sensitivities and remove trigger foods (such as gluten). ZnC is perhaps best known for its approved use in Japan for the management of stomach ulcers. In a randomized, controlled, double-blind study, 258 subjects with confirmed stomach ulcers were randomly assigned to receive 150 mg ZnC per day, a placebo, 800 mg of cetraxate hydrochloride (a known mucosal protection agent), or its placebo for 8 weeks. Endoscopy was done before and after treatment and subjective measures of symptoms were collected. Symptoms were 61% better in the marked improvement category in the ZnC group and 61.5% in the cetraxate group at 4 weeks. At 8 weeks, the ZnC group increased to 75% markedly improved compared to 72% for the cetraxate group. The endoscopic cure rate was 26.3% in the ZnC group and 16.2% in the cetraxate group at 4 weeks and 60.4% in the ZnC group and 46.2% in the cetraxate group at 8 weeks. This suggests that ZnC can provide superior relief of symptoms and improvement in gastric ulcers compared to a known mucosal protection agent [ 12]. Another study by the same group using 50, 75, or 100mg twice daily showed improvement in symptoms and the endoscopic healing rate at all three doses [ 53]. Other human clinical trials support these results at doses of 50, 75, and 100 mg twice a day [ 13, 14, 15, 16, 17].
Learning all the natural ways of relieving and preventing gas, gluten intolerance, IBS, lactose intolerance, bloating, diarrhea and constipation along with taking Doctor’s Best PepZin GI is something that you will be happy about in the future. Achieving the best results in relieving digestive issues can’t be relied solely on Doctor’s Best PepZin GI. If you are at the point where your digestive issues become unbearable then committing to a proper diet and changes in your lifestyle are just as crucial as taking anything over the counter. Adhering to a low sugar diet is one of the bigger commitments women will have to make in relieving and preventing digestive problems. Leech B, Schloss J, Steel A. Association between increased intestinal permeability and disease: A systematic review. Advances in Integrative Medicine. 2019;6(1):23-34. doi:10.1016/j.aimed.2018.08.003Prescriptions must be written on an Authority Prescription Form, and the approval number must be noted on the prescription. Pharmacists cannot dispense the item as a pharmaceutical benefit unless it has been approved by Medicare Australia (indicated by the presence of the approval number). The gut lining — aka the intestinal barrier — serves as a major line of defense for the human body. Under normal conditions, this remarkably complex barrier must maintain selective permeability, which means that it must selectively allow “good” guys (like water and nutrients) to pass into circulation while keeping out the “bad” guys (like pathogenic microbes, proinflammatory compounds, endotoxins and undigested compounds). Take one (1) capsule twice (2) daily -- once after breakfast and once before bed. For added support, take two (2) capsules twice (2) daily.
Ishihama, H.; Sayo, S.; Yokoyama, T.; Ueno, M.; Ebihara, N.; Doi, Y.; Asano, K.; Kawamata, H.; Imai, H.; Ueki, K. P1–032preventive and Therapeutic Effects of Polaprezinc Suspension on Oral Mucosal Injury. Ann. Oncol. 2013, 24, ix68. [ Google Scholar] [ CrossRef][ Green Version] Himoto, T.; Hosomi, N.; Nakai, S.; Deguchi, A.; Kinekawa, F.; Matsuki, M.; Yachida, M.; Masaki, T.; Kurokochi, K.; Watanabe, S. Efficacy of zinc administration in patients with hepatitis C virus-related chronic liver disease. Scand. J. Gastroenterol. 2007, 42, 1078–1087. [ Google Scholar] [ CrossRef]Rasmussen, V.F.; Vestergaard, E.T.; Hejlesen, O.; Andersson, C.U.N.; Cichosz, S.L. Prevalence of taste and smell impairment in adults with diabetes: A cross-sectional analysis of data from the National Health and Nutrition Examination Survey (NHANES). Prim. Care Diabetes 2018, 12, 453–459. [ Google Scholar] [ CrossRef] There’s a chance the problem may be leaky gut. That’s when unhealthy intestinal permeability allows foreign invaders to leak into your body. And that can cause unwanted inflammation and a dysfunctional immune system. Choi, H.S.; Kim, E.S.; Keum, B.; Chun, H.J.; Sung, M.-K. L-Carnosine and Zinc in Gastric Protection. In Betaine Chemistry, Analysis, Function and Effects; Royal Society of Chemistry: London, UK, 2015; pp. 548–565. [ Google Scholar] [ CrossRef]
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