SANPROBI IBS, CAPSULES results in a reduction of abdominal pain, bloating, and normalization of bowel movements 20 PCS.

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Elbere I, Kalnina I, Silamikelis I, Konrade I, Zaharenko L, Sekace K, Radovica-Spalvina I, Fridmanis D, Gudra D, Pirags V, Klovins J. Association of metformin administration with gut microbiome dysbiosis in healthy volunteers. PLoS One. 2018 Sep 27;13(9):e0204317. doi: 10.1371/journal.pone.0204317. eCollection 2018. The intervention factor was the SANPROBI BARRIER multi-strain probiotic (commonly available in pharmacies) or placebo (created on the model of a probiotic capsule, specially for the needs of research, by Sanprobi Sp. z o.o.). A gluten-free diet and probiotic supplementation, separately and in combination, have received much attention as a potential therapeutic strategy. This approach is of particular interest as it considers that a gluten-free diet changes the microbiota profile and alters the activity of microbiota-mediated biochemical pathways [ 85, 86]. Notably, the microbiota is able to digest gluten. Bacterial and fungi enzymes are involved in gluten break-down and the formation of peptides with different immunogenic capacities [ 87, 88]. Hence, gut dysbiosis could intensify the immunogenic effect of cereal-derived compounds [ 89]. Studies have confirmed differences in gut microbiota of patients with celiac disease and non-celiac gluten sensitivity (NCGS) [ 90, 91]. Eubiosis is necessary for both appropriate gut function and restoration of intestinal barrier integrity, [ 87, 88, 92]. Stool collection for microbial analysis, short chain fatty acids, zonulin and calprotectin concentration. A growing amount of evidence indicates that microbiota eubiosis may be one of the potential factors supporting gut function and proper communication between the gut and the brain [ 15– 17]. The gut microbiota performs essential functions influencing gut wall integrity (i.e. the upregulation of mucin genes, immunoglobulin A (sIgA), and cytokine secretion, suppression of intestinal inflammation, and restoration of TJs structure [ 18]. Gut dysbiosis affects alternations in intestinal permeability [ 19, 20]. Beyond the macrophage theory of depression, microbial dysbiosis is associated with impaired epithelial barrier, bacterial translocation, decreased regulatory T cells in the gut mucosa, and has been shown to promote inflammation [ 21]. A quantitative and qualitative recovery within the composition of microbiota could therefore have a beneficial effect on inflammation and the regulation of transport via the gut to blood circulation [ 22– 24].

Schmitz L, Ferrari N, Schwiertz A, Rusch K, Woestmann U, Mahabir E, Graf C. Impact of endurance exercise and probiotic supplementation on the intestinal microbiota: a cross-over pilot study. Pilot Feasibility Stud. 2019 Jun 8;5:76. doi: 10.1186/s40814-019-0459-9. eCollection 2019. Competitors used probiotic/ placebo for three months at a dose of 2x2 capsules daily (2.5 x 10 9 CFU / g (1 capsule)). Fasting state. Blood pressure, heart rate, BMI measurements, WHR. Blood collection for zonulin and immunoglobulins against zonulin, calprotectin, CRP, HbA1c, HGB, RBC, WBC, PLT, creatinine, lipogram, ALT activity and oxidative stress parameters (SOD, GPx,CAT, GR, TOC, LPS, PSH, MDA, GSH, TAS (TAC).) .During the test, the maximum test procedure was used to obtain more test parameters, and the test condition was considered to be 90% HRmax by the test subject, or the test could not be continued by interrupting it at the test subject's request. Body composition analysis All competitors underwent body composition analysis using the InBody model 770 analyzer (South Korea). Therefore, it has been speculated that metformin's versatile effect mediated through the gut microbiota is responsible not only for its therapeutic effect but also for its undesirable digestive symptoms.

The study consisted of two stages (W1 and W2), and each stage was associated with three visits by the participants. kapsułka zawierabakterii ≥2.5 x 10 9 CFU/g żywych szczepów bakterii: Bifidobacterium lactis W52, Lactobacillus brevis W63, Lactobacillus casei W56, Lactococcus lactis W19, Lactococcus lactis W58, Lactobacillus acidophilus W37, Bifidobacterium bifidum W23, Bifidobacterium lactis W51, Lactobacillus salivarius W24. ABriones M., Touyz R.M. Oxidative stress, and hypertension: Current concepts. Curr. Hypertens. Rep. 2010;12:135–142. doi: 10.1007/s11906-010-0100-z. Visit 3 - month 1 (4 weeks ± 3 days from the visit 2) Gastrointestinal symptoms questionnaire administration. This incredibly advanced functional system created by the mucous membrane of enterocytes and microorganisms that live there is unfortunately extremely susceptible to damages. The largest devastation in the natural bacterial microflora is made by antibiotics, still very willingly prescribed by doctors. Importantly, they cause changes in the bacterial composition of the digestive system not only during their application, but they also have influence on the probiotic barrier for many years after antibiotic therapy.The research was carried out at the Department of Dietetics and Clinical Nutrition (Medical University of Bialystok), Fitness Club Maniac Gym in Bialystok, as well as at the Hematological Diagnostics Department and the Biochemical Diagnostics Department of the University Teaching Hospital in Bialystok.

Skrobia kukurydziana, maltodekstryny, białko roślinne, Bifidobacterium Iactis W52; Lactobacillus brevis W63; Lactobacillus casei W56; Lactococcus lactis W19; Lactococcus lactis W58; Lactobacillus acidophilus W37; Bifidobacterium bifidum W23; Lactobacillus salivarius W24; otoczkakapsułki: hydroksypropylometyloceluloza.Patients will fill out questionnaires regarding the gastrointestinal symptoms associated with metformin at a dose they did not tolerate and at a time of reduced daily dose of metformin they do tolerate (patients are accepted to have gastrointestinal symptoms which they accept). None of the competitors had an implanted pacemaker, which is an absolute exclusion criterion in the study of body composition analysis by electrical bioimpedance.