Enterogermina 2 Billion (10 Vials)

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Gueimonde M, Sánchez B. G de Los Reyes-Gavilán C. Margolles A Antibiotic resistance in probiotic bacteria Front Microbiol. 2013;4:202. https://doi.org/10.3389/fmicb.2013.00202. Marseglia GL, Tosca M, Cirillo I, Licari A, Leone M, Marseglia A, et al. Efficacy of Bacillus clausii spores in the prevention of recurrent respiratory infections in children: a pilot study. Ther Clin Risk Manag. 2007;3:13–7. https://doi.org/10.2147/TCRM.2007.3.1.13. Pregnancy, planning to conceive and lactating mothers. Enterogermina has not been shown to harm the growing baby or nursing baby. But it should be used with caution with the advice of your doctor.

Zhu T, Pan Z, Domagalski N, Koepsel R, Ataai MM, Domach MM. Engineering of Bacillus subtilis for enhanced total synthesis of folic acid. Appl Environ Microbiol. 2005;71:7122–9. https://doi.org/10.1128/AEM.71.11.7122-7129.2005. Hagenbuch B, Dawson P. The sodium bile salt cotransport family SLC10. Pflugers Arch - Eur J Physiol. 2004;447:566–70. https://doi.org/10.1007/s00424-003-1130-z. Pradhan B, Guha D, Ray P, Das D, Aich P. Comparative analysis of the effects of two probiotic bacterial strains on metabolism and innate immunity in the RAW 264.7 murine macrophage cell line. Probiotics Antimicrob Proteins. 2016;8:73–84. https://doi.org/10.1007/s12602-016-9211-4.Another bacteria can also be used in some countries, which is Bacillus substilis. The suspension is in distilled water that has been sterilized. Bacillus clausii in Enterogermina are alive and maintain a mutually beneficial relationship with the host. Dosage In the mucus of the proximal colon, PPI treatment in the PPI control arm led to significant decreases in Prevotellaceae in the TR stage compared with the C stage ( p = 0.001; Table 9 and Table S5); this was rescued by probiotic treatment as seen by the higher levels of this family in the TR stage of the preventive arm compared with the TR stage of the PPI control arm ( p< 0.001; Table 9 and Table S5) and by the higher levels in the WO stage of the curative arm compared with the WO stage of the PPI control arm ( p = 0.029; Table 9 and Table S5), though these increases in the TR stage of the preventive and WO stage of the curative arms were not significantly different from the respective C stages ( Table 9 and Table S5). Enterogermina contains spores of Bacillus clausii a bacteria that lives in soil, and it is gram-positive and rod-shaped. Bacillus clausii is a good bacteria, that when taken restores the balance that had been lost, relieving disease symptoms. Bacillus clausii is symbiotic and thus beneficial to the host. Also, Enterogermina improves the absorption of nutrients from the intestine and enhances the body’s natural defenses. In the long run, it improves the body’s immune system in general. Facts on Enterogermina

Enterogermina ® (Sanofi) is a probiotic comprising four strains of Bacillus clausii (O/C, N/R, SIN, and T) that has been used effectively and safely for several decades [ 11]. Enterogermina was used as an adjunct to triple therapy (i.e., alongside two antibiotics and a PPI) in the treatment of Helicobacter pylori infections [ 11] and has been shown to reduce the adverse effects, such as diarrhea, nausea, and pain, which were largely attributed to the antibiotic component of the therapy [ 12]. Even though B. clausii has been in use for decades, several of its mechanisms of action have only been described in recent years, in the context of rotaviral infections and as a probiotic with antimicrobial and immunomodulatory activity [ 13, 14, 15]. Marshall B, Petrowski D, Levy SB, Summers AO. Inter- and intraspecies spread of Escherichia coli in a farm environment in the absence of antibiotic usage. Proc Natl Acad Sci U S A. 1990;87:6609–13. https://doi.org/10.1073/pnas.87.17.6609.

Schallmey M, Singh A, Ward OP. Developments in the use of Bacillus species for industrial production. Can J Microbiol. 2004;50:1–17. https://doi.org/10.1139/w03-076.

Enterogermina is classified by the FDA as a pregnancy category A as it has shown no risk to the growing fetus.During the two-week control period (C), basic nutritional matrix supplementation was continued. Samples collected in this period were used to determine the baseline microbial community composition and activity as a reference for the treatment arms. Sampling frequency is described separately for each experiment in the sections below. During the two-week treatment period (TR), the reactors were supplemented with the PPI omeprazole (14 mg/day added to the ileum to closely mimic repeated intake of PPIs) under the following conditions: (1) PPI alone (PPI control); (2) simultaneous PPI + Enterogermina (preventive); and (3) PPI for 2 weeks followed by Enterogermina (curative). Enterogermina was administered at a daily dose of 6 × 10 9 colony-forming units in the preventive and curative arms. During the two-week washout period (WO), PPI treatment was withdrawn from all arms, and Enterogermina supplementation was withdrawn from arm 2 and initiated in arm 3 at the same dose as was used in the preventive arm. Porwal S, Lal S, Cheema S, Kalia VC. Phylogeny in aid of the present and novel microbial lineages: diversity in Bacillus. PLoS One. 2009;4:e4438. https://doi.org/10.1371/journal.pone.0004438.