FLOPLAST 110MM UNIVERSAL PIPE CONNECTOR - ADAPTS TO SOIL/CLAY/DRAINAGE

Product Information

Traditionally cast iron was used for a whole host of applications including gates and railings, barriers, seating, ornamental structures and also plumbing including foul waste removal (soil pipe) and guttering. Nagasawa M, Tomimatsu K, Terada K, Kondo K, Miyazaki K, Miyazaki M, et al. Long non-coding RNA MANCR is a target of BET bromodomain protein BRD4 and plays a critical role in cellular migration and invasion abilities of prostate cancer. Biochem Biophys Res Commun. 2020;526(1):128–34. Colour matching between systems facilitates colour co-ordination where sanitary pipework is located externally. Department of Clinical Genetics, Genome Diagnostics Laboratory, Amsterdam Reproduction & Development, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands

The Timesaver coupling is one of the oldest types of pipe couplings first appearing on the market in the early 70’s and has remained a proven for of pipe joining since then. Patel U, Rajasingh S, Samanta S, Cao T, Dawn B, Rajasingh J. Macrophage polarization in response to epigenetic modifiers during infection and inflammation. Drug Discov Today. 2017;22(1):186–93. Butler A, Hoffman P, Smibert P, Papalexi E, Satija R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat Biotechnol. 2018;36(5):411–20. Stark GR, Kerr IM, Williams BR, Silverman RH, Schreiber RD. How cells respond to interferons. Annu Rev Biochem. 1998;67:227–64.

Intuitive 3-button controller

Martin JC, Chang C, Boschetti G, Ungaro R, Giri M, Grout JA, et al. Single-cell analysis of Crohn's disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy. Cell. 2019;178(6):1493–508.e20. These connectors are very effective and certainly do the job and they can also be used to connect pipework underground, however when used over ground they are a little unsightly.

As many over the years had encountered this problem some clever individuals came up with some innovative products that allowed you to join your new pipework at the point the old cast iron pipework disappeared underground, here are some of the best ones. Gene Ontology analysis of SP140-bound genes showed enrichment of genes that participate in the processes of cytokine response and immune response that were inhibited through GSK761 pre-exposure (Fig. 6h). To elucidate the regulatory pathways enriched by SP140 and affected by GSK761, we carried out hallmark pathway analysis for SP140 differentially bound genes (DBGs) (Fig. 6i) and DEGs (Fig. 6j) upon DMSO or GSK761 treatment at each time point of LPS stimulation. In DMSO-treated “M1” macrophages, we found that SP140 binding is predominantly enriched at many pathways typically defined as inflammatory such as TNF signaling via NFKB, and inflammatory response (Fig. 6i). However, this enrichment was no longer seen in GSK761-treated macrophages (Fig. 6i). Similar pathways were observed for DEGs and were downregulated in GSK761-treated macrophages, especially at 4 h (Fig. 6j). In addition, we observed an upregulation of MYC targets and oxidative phosphorylation gene sets in GSK761-treated macrophages, whereas these normally are downregulated because of the induction of aerobic glycolysis upon LPS stimulation of macrophages (Additional file 1: Fig. S8a) [ 38]. These data suggest SP140 as a critical regulator of genes involved in the inflammatory response and that GSK761 can inhibit this response through displacing SP140 binding to TSS and enhancer regions. SP140 preferentially controls the expression of specific gene sets involved in the innate immune responseFranke A, McGovern DPB, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet. 2010;42(12):1118–25. Our Plastic Fittings range includes: Embrass Peerless, Floplast, Philmac and Pushfit Fittings (including Speedfit, Polyplumb and Polyfit). Zucchelli C, Tamburri S, Filosa G, Ghitti M, Quilici G, Bachi A, et al. Sp140 is a multi-SUMO-1 target and its PHD finger promotes SUMOylation of the adjacent Bromodomain. Biochim Biophys Acta Gen Subj. 2019;1863(2):456–65.

Compatible with most other existing materials and systems manufactured to British/European Standards. Koelink PJ, Bloemendaal FM, Li B, Westera L, Vogels EWM, van Roest M, et al. Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling. Gut. 2020;69(6):1053. Although this is technically the correct path to take as you can appreciate it’s a lot of hassle and expense and if you can simply join to the old pipe using a suitable connector this is many ways will probably be the best way to go.Ray G, Longworth MS. Epigenetics, DNA organization, and inflammatory bowel disease. Inflamm Bowel Dis. 2019;25(2):235–47. Ge SX, Jung D, Yao R. ShinyGO: a graphical gene-set enrichment tool for animals and plants. Bioinformatics. 2019;36(8):2628-9. Ghiboub M, Elfiky AMI, de Winther MPJ, Harker NR, Tough DF, de Jonge WJ. Selective Targeting of Epigenetic Readers and Histone Deacetylases in Autoimmune and Inflammatory Diseases: Recent Advances and Future Perspectives. J Pers Med. 2021;11(5):336. Mehta S, Cronkite DA, Basavappa M, Saunders TL, Adiliaghdam F, Amatullah H, et al. Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140. Sci Immunol. 2017;2(9):eaag3160.

Fittings have an aesthetic modern look, are compatible in size yet remain within the British Standard Specification. Steinbach EC, Plevy SE. The role of macrophages and dendritic cells in the initiation of inflammation in IBD. Inflamm Bowel Dis. 2014;20(1):166–75. Street K, Risso D, Fletcher RB, Das D, Ngai J, Yosef N, et al. Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics. BMC Genomics. 2018;19(1):477. Cho J MJ, Merad M, Kenigsberg E, Giri M. Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy. GEO. (2019). https://identifiers.org/geo:GSE134809.To all Corsair Link Commander mini owners – If you already have our HD120/SP120 RGB fans, please DO NOT connect the 5V 4pin LED connector to your Commander mini LED port as those ports runs on 12V. We know that the pins are keyed the same on the connector and the Commander mini LED port, so I know for a fact that this part can be easily overlooked when connecting the fans. Regad T, Chelbi-Alix MK. Role and fate of PML nuclear bodies in response to interferon and viral infections. Oncogene. 2001;20(49):7274–86.