N / C 100 5ml needleless plastic syringes, can be used multiple times, suitable for scientific laboratory, metering, watering, adding water, refueling

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excipients examples include pharmaceutical grades of dextrose, sucrose, lactose, trehalose, mannitol, sorbitol, inositol, dextran, starch, cellulose, sodium or calcium phosphates, calcium sulfate, citric acid, tartaric acid, glycine, high molecular weight polyethylene glycols (PEG), and combinations thereof. Such filters have an upper limit to gas velocity through the filter so as to ensure that they operate to the specification. shows a sixth embodiment of the invention which combines many of The features of the previously described embodiments but also has a novel actuating Mechanism which serves to align the powder cassette plug 52 into the operating position and Actuates the cylinder fracturing mechanism in one simple operation. and it has been found that the transsonic gas jet formed effectively entrains the particles such that they are uniformly distributed in the gas flow. When 30 bar driver pressure is used, this corresponds to a pressure difference of 6 bar which serves to draw the particles into the flow.

This FDA safety warning about DIY needle-free devices applies to pens that are sold as a needle-free way to inject fillers at home. analyte is used herein in its broadest sense to denote any specific substance or component that one desires to detect and/or measure in a physical, chemical, biochemical, electrochemical, photochemical, spectrophotometric, polarimetric, colorimetric, or radiometric analysis. By distributing the particles in the flow of gas from a needleless syringe using the method of the above first aspect of the present invention, whilst the nozzle's downstream exit is positioned adjacent a target area of skin or mucosa, the particles may be administered to the skin or mucosa. the main body 1 of the syringe has a central aperture extending therethrough to form a lumen which bounds the gas flow path through the syringe, into the downstream end of which is fitted a nozzle 2. September 1966: The Star Trek series started to use its own jet injector device under the name " hypospray".Where the nozzle has a divergent downstream section, it has been found that by extending the length of the nozzle to increase the diameter of the nozzle at its downstream exit, significantly larger target areas on the skin or mucosa may be penetrated by the particles, with good uniformity of distribution across the larger target area. Examples of suitable surfactants include, for example, Tergitol® and Triton® surfactants (Union Carbide Chemicals and Plastics, Danbury, Conn. the good distribution of particles across a target area substantially equal to the size of the nozzle at the nozzle's downstream exit is influenced by the relative minimum sizes of the first and second convergences 5 , 16 , the distance by which they are spaced apart and the positioning of the particle inlet passage 10 relative to the exit of the first convergence and the entrance to the second convergence.

Such materials can be used as stabilizers, anti-oxidants, or used to reduce the possibility of local irritation at the site of administration. From 1984 to 1985, a weight-loss clinic in Los Angeles administered human chorionic gonadotropin (hCG) with a Med-E-Jet injector. This is the earliest documented jet injector to administer water or medicine under enough pressure to penetrate the skin without the use of a needle. The ratio of flow cross-sections between the first and second convergences 5, 9 is relevant to the functioning of the syringe.

is a top plan view of the target area of a gel target, a side cross-sectional view through the gel target and an enlarged side cross-sectional view through the gel target after the firing at it of particles from the syringe shown in FIG. the particles are more uniformly dispersed over the target and the maximum penetration is still 250 ⁇ m.

the downstream tip of the sonic nozzle 4 defining the first convergence 5 (in turn comprising constrictions 5a and 5b), is generally coincident with the central longitudinal axis of the particle inlet passage 10. This sonic nozzle 4 is provided with an aperture which forms a first convergence or constriction 5 to the flow of gas through the main body 1. is a reconstruction of a diametral 10 mm wide slice through the agar target, showing the uniformity of distribution and penetration of the particles across the full width of the target. the third embodiment works in a very similar way to the first and second embodiments in so far as there is provided a first convergence or constriction followed by a chamber of increased cross-section followed by another convergence or constriction. Further increase of the gas pressure causes the pressure in the chamber 8 to rise above that of the atmosphere which results in the particles being ejected from the air aspiration hole.

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is a top plan view of the target area of the gel target, a side cross-sectional view through the gel target and an enlarged side cross-sectional view through the gel target respectively, after the firing at it of particles from the syringe shown in FIG. the particles may be initially lightly adhered to the inside of a tubular member which is initially provided in the gas flow path. The upstream end of the nozzle 2 forms a second convergence or constriction 9 to the flow of gas through the main body 1. the particle payload can be introduced at any point in the gas flow where the pressure is low enough to cause the drawing-in effect to take place.suitable surfactants include, for example, Tergitol® and Triton® surfactants (Union Carbide Chemicals and Plastics, Danbury, Conn. the particle source 11 whilst suitable for use in the laboratory, would not be particularly well suited to commercial use because the powder to be delivered could become contaminated and/or fall out of the reservoir provided in the particle source cassette. In another aspect of the invention, there is provided a method of creating a gas flow in a needleless syringe which comprises flowing gas through a first convergence into a chamber to form a transsonic gas jet in the chamber and passing the gas jet from the chamber into a second convergence and along the nozzle. Even if the product is trending on social media, remember that these devices can cause serious injury.